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Xu, Chenqi
Institute of Biochemistry and Cell Biology

Research Focus

lymphocyte signaling

The long-term interest of the Xu lab is to study how does the extracellular signals cross the plasma member via surface receptors. Particular attention will be given to key immunoreceptors, especially those in T cells. The prevailing idea about receptor activation is that the ligand binding on the extracellular part of the receptor will cause physical forces to induce intracellular signaling. We will instead investigate the impact of membrane environment on receptor triggering. Plasma membrane provides a unique lipid bilayer environment for membrane receptor assembly and signal transduction. Moreover, the asymmetry of the membrane is critical for the receptor function. We will utilize biochemical, biophysical and cellular approaches to study the relevance of membrane environment change on receptor signaling.

Nov. 2009- present, Principle Investigator, Institute of Biochemistry and Cell Biology, SIBS
Apr.-Sep. 2009, Instructor, Dana-Farber Cancer Institute, Harvard Medical School
Aug. 2004-Mar. 2009, Postdoctoral Fellow, Dana-Farber Cancer Institute, Harvard Medical School
Jul. 2004, Ph.D. Institute of Biochemistry and Cell Biology, SIBS

Selected Publications

1、Shi X*, Bi Y*, Yang W*, Guo X, Jiang Y, Wan C, Li L, Bai Y, Guo J, Wang Y, Chen X, Wu B, Sun H, Liu W, Wang J#, Xu C#. Ca2+ regulates T cell receptor activation by modulating the electrostatic property of phospholipids, Nature, in press. (*first author, #corresponding author)
2、Xu C*, Gagnon E*, Call ME, Schnell JR, Schwieters CD, Carman CV, Chou JJ, Wucherpfennig KW. Regulation of T cell Receptor Activation by Dynamic Membrane Binding of the CD3e Cytoplasmic Tyrosine-Based Motif. Cell 2008, 135, 702-713 (*first author)
3、Gagnon E, Xu C, Yang W, Chu HH, Call ME, Chou JJ, Wucherpfennig KW. Response multilayered control of T cell receptor phosphorylation. Cell 2010, 142, 669-71.
4、Wang S, Huang L, Wicher D, Chi C, Xu C. Structure-function relationship of bifunctional scorpion toxin BmBKTx1. Acta Biochim Biophys Sin (Shanghai). 2008, 40:955-63.
5、Xu C, Call ME, Wucherpfennig KW., A membrane-proximal tetracysteine motif contributes to assembly of cd3de and cd3ge dimers with the T cell receptor. Journal of Biological Chemistry 2006 281, 36977-36984.
6、O’Connor KC*, McLaughlin KA*, De Jager PL, Chitnis T, Bettelli E, Xu C, Robinson WH, Cherry SV, Bar-Or A, Banwell B, Fukaura H, Fukazawa T, Tenembaum S, Wong SJ, Tavakoli NP, Idrissova Z, Viglietta V, Rostasy K, Pohl D, Dale RC, Freedman M, Steinman L, Buckle GJ, Kuchroo VK, Hafler DA, Wucherpfennig KW Self-assembling Antigen Tetramers Permit Discrimination of Autoantibodies to Folded and Denatured Self-antigens in Demyelinating Diseases Nature Medicine 2007, 13, 211-217. (*first author)
7、Call ME*, Schnell JR*, Xu C, Lutz RA, Chou JJ, Wucherpfennig KW. The Structure of the ζζ Transmembrane Dimer Reveals Polar Features Essential for Dimerization and Assembly with the T cell Receptor Cell, 2006, 127, 355-68. (*first author)
8、Jiang H, Xu CQ, Wang CZ, Fan CX, Zhao TY, Chen JS, Chi CW Two novel O-superfamily conotoxins from Conus vexillum Toxicon. 2006, 47, 425-36
9、Jiang H, Wang CZ, Xu CQ, Fan CX, Dai XD, Chen JS, Chi CW.A novel M-superfamily conotoxin with a unique motif from Conus vexillum Peptides. 2006 27, 682-9. 
10、Xu CQ*, Br?ne B*, Wicher D, Bozkurt O, Lu WY, Huys I, Han YH, Tytgat J, Van Kerkhove E, Chi CW. BmBKTx1, a novel Ca2+-activated K+ channel blocker purified from the Asian scorpion Buthus martensi Karsch. Journal of Biological Chemistry 2004; 279: 34562-9. (*first author)
11、Xu CQ, He LL, Br?ne B, Martin-Eauclaire MF, Van Kerkhove E, Zhou Z, Chi CW. A novel scorpion toxin blocking small conductance Ca2+ activated K+ channel. Toxicon. 2004; 43: 961-71.
12、Cai Z*, Xu C*, Xu Y, Lu W, Chi CW, Shi Y, Wu J.. Solution structure of BmBKTx1, a new BKCa1 channel blocker from the Chinese scorpion Buthus martensi Karsch. Biochemistry. 2004; 43: 3764-71. (*first author)
13、Huys I*, Xu CQ*, Wang CZ, Vacher H, Martin-Eauclaire MF, Chi CW, Tytgat J. BmTx3, a scorpion toxin with two putative functional faces separately active on A-type K+ and HERG currents. Biochemical Journal 2004; 378: 745-52. (*first author)
14、Frénal K*, Xu CQ*, Wolff N, Wecker K, Gurrola GB, Zhu SY, Chi CW, Possani LD, Tytgat J, Delepierre M. Exploring structural features of the interaction between the scorpion toxinCnErg1 and ERG K+ channels. PROTEINS: Structure, Function, and Bioinformatics. 2004; 56: 367-75. (*first author)
15、Szyk A, Lu WY, Xu C, Lubkowski J. Structure of the Scorpion Toxin BmBKTx1 Solved from Single Wavelength Anomalous Scattering of Sulfur. Journal of Structural Biology 2004; 145: 289-94.
16、Xu CQ, Zhu SY, Chi CW, Tytgat J. Turret and pore block of K+ channels: what is the difference? TRENDS in Pharmacological Sciences. 2003; 24: 446-8.


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