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论文题目: Association study of TPH2 polymorphisms and bipolar disorder in the Han Chinese population
英文论文题目: Association study of TPH2 polymorphisms and bipolar disorder in the Han Chinese population
第一作者: Chen, S; Huang, XY; Yu, T; Li, X; Cao, YF; Li, XW; Xu, F; Yang, FP; Jesse, FF; Xu, MQ; Li, WD; He, L; He, G
英文第一作者: Chen, S; Huang, XY; Yu, T; Li, X; Cao, YF; Li, XW; Xu, F; Yang, FP; Jesse, FF; Xu, MQ; Li, WD; He, L; He, G
联系作者: He, L (reprint author), Shanghai Jiao Tong Univ, Bio X Inst, 1954 Huashan Rd, Shanghai 200030, Peoples R China.
英文联系作者: He, L (reprint author), Shanghai Jiao Tong Univ, Bio X Inst, 1954 Huashan Rd, Shanghai 200030, Peoples R China.
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发表年度: 2015
卷: 56
期:
页码: 97-100
摘要: Objective: Bipolar disorder (BPD) is a serious and common mental disorder with high heritability. The serotonergic system is known to be implicated in the etiology of the disorder. Tryptophan hydroxylase isoform-2 (TPH2), which controls the synthesis of serotonin in the brain, has been suggested as a candidate gene for BDP. The aim of this study was to examine the association between the polymorphisms in TPH2 and BPD. Methods: We conducted a case-control study by genotyping six SNPs (rs10784941, rs1386494, rs2171363, rs4760816, rs1386486, and rs1872824) in 506 bipolar patients and 507 controls of Chinese Han origin. Results: rs10784941 was not in the Hardy-Weinberg equilibrium and therefore excluded from further analysis. rs1386486 and rs1872824 showed statistically significant differences between cases and controls in genotype frequencies (rs1386486: p = 0.043351; rs1872824: p = 0.016563), but no association in allele frequencies. Strong LD was found among rs1386494, rs2171363 and rs4760816, but no positive association with BPD was found for haplotypes. Conclusion: Our results indicate that in the Han Chinese population TPH2 may be a potential susceptibility gene for bipolar disorder. Further studies are needed to validate this association. (C) 2014 Elsevier Inc. All rights reserved.
英文摘要: Objective: Bipolar disorder (BPD) is a serious and common mental disorder with high heritability. The serotonergic system is known to be implicated in the etiology of the disorder. Tryptophan hydroxylase isoform-2 (TPH2), which controls the synthesis of serotonin in the brain, has been suggested as a candidate gene for BDP. The aim of this study was to examine the association between the polymorphisms in TPH2 and BPD. Methods: We conducted a case-control study by genotyping six SNPs (rs10784941, rs1386494, rs2171363, rs4760816, rs1386486, and rs1872824) in 506 bipolar patients and 507 controls of Chinese Han origin. Results: rs10784941 was not in the Hardy-Weinberg equilibrium and therefore excluded from further analysis. rs1386486 and rs1872824 showed statistically significant differences between cases and controls in genotype frequencies (rs1386486: p = 0.043351; rs1872824: p = 0.016563), but no association in allele frequencies. Strong LD was found among rs1386494, rs2171363 and rs4760816, but no positive association with BPD was found for haplotypes. Conclusion: Our results indicate that in the Han Chinese population TPH2 may be a potential susceptibility gene for bipolar disorder. Further studies are needed to validate this association. (C) 2014 Elsevier Inc. All rights reserved.
刊物名称: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
英文刊物名称: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
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学科: Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
英文学科: Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
影响因子: 3.689
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论文类别: Article
英文论文类别: Article
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