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论文题目: Topological, functional, and dynamic properties of the protein interaction networks rewired by benzo(a)pyrene
英文论文题目: Topological, functional, and dynamic properties of the protein interaction networks rewired by benzo(a)pyrene
第一作者: Ba, Q; Li, JY; Huang, C; Li, JQ; Chu, RA; Wu, YN; Wang, H
英文第一作者: Ba, Q; Li, JY; Huang, C; Li, JQ; Chu, RA; Wu, YN; Wang, H
联系作者: Wu, YN (reprint author), Minist Hlth, Key Lab Food Safety Risk Assessment, 7 Panjiayuan Nanli, Beijing 100021, Peoples R China.
英文联系作者: Wu, YN (reprint author), Minist Hlth, Key Lab Food Safety Risk Assessment, 7 Panjiayuan Nanli, Beijing 100021, Peoples R China.
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发表年度: 2015
卷: 283
期: 2
页码: 83-91
摘要: Benzo(a)pyrene is a Common environmental and foodborne pollutant that has been identified as a human carcinogen. Although the carcinogenicity of benzo(a)pyrene has been extensively reported, its precise molecular mechanisms and the influence on system-level protein networks are not well understood. To investigate the system-level influence of benzo(a)pyrene on protein interactions and regulatory networks, a benzo(a)pyrene-rewired protein interaction network was constructed based on 769 key proteins derived from more than 500 literature reports. The protein interaction network rewired by benzo(a)pyrene was a scale-free, highly-connected biological system. Ten modules were identified, and 25 signaling pathways were enriched, most of which belong to the human diseases category, especially cancer and infectious disease. In addition, two lung-specific and two liver-specific pathways were identified. Three pathways were specific in short and medium-term networks (<48 h), and five pathways were enriched only in the medium-term network (6 h-48 h). Finally, the expression of linker genes in the network was validated by Western blotting. These findings establish the overall, tissue- and time-specific benzo(a)pyrene-rewired protein interaction networks and provide insights into the biological effects and molecular mechanisms of action of benzo(a)pyrene. (C) 2015 Elsevier Inc. All rights reserved.
英文摘要: Benzo(a)pyrene is a Common environmental and foodborne pollutant that has been identified as a human carcinogen. Although the carcinogenicity of benzo(a)pyrene has been extensively reported, its precise molecular mechanisms and the influence on system-level protein networks are not well understood. To investigate the system-level influence of benzo(a)pyrene on protein interactions and regulatory networks, a benzo(a)pyrene-rewired protein interaction network was constructed based on 769 key proteins derived from more than 500 literature reports. The protein interaction network rewired by benzo(a)pyrene was a scale-free, highly-connected biological system. Ten modules were identified, and 25 signaling pathways were enriched, most of which belong to the human diseases category, especially cancer and infectious disease. In addition, two lung-specific and two liver-specific pathways were identified. Three pathways were specific in short and medium-term networks (<48 h), and five pathways were enriched only in the medium-term network (6 h-48 h). Finally, the expression of linker genes in the network was validated by Western blotting. These findings establish the overall, tissue- and time-specific benzo(a)pyrene-rewired protein interaction networks and provide insights into the biological effects and molecular mechanisms of action of benzo(a)pyrene. (C) 2015 Elsevier Inc. All rights reserved.
刊物名称: TOXICOLOGY AND APPLIED PHARMACOLOGY
英文刊物名称: TOXICOLOGY AND APPLIED PHARMACOLOGY
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学科: Pharmacology & Pharmacy; Toxicology
英文学科: Pharmacology & Pharmacy; Toxicology
影响因子: 3.705
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论文类别: Article
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