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论文题目: Genetic loci associated with circulating levels of very long-chain saturated fatty acids
英文论文题目: Genetic loci associated with circulating levels of very long-chain saturated fatty acids
第一作者: Lemaitre, RN; King, IB; Kabagambe, EK; Wu, JHY; McKnight, B; Manichaikul, A; Guan, WH; Sun, Q; Chasman, DI; Foy, M; Wang, L; Zhu, JW; Siscovick, DS; Tsai, MY; Arnett, DK; Psaty, BM; Djousse, L; Chen, YDI; Tang, WH; Weng, LC; Wu, HY; Jensen, MK; Chu, AY; Jacobs, DR; Rich, SS; Mozaffarian, D; Steffen, L; Rimm, EB; Hu, FB; Ridker, PM; Fornage, M; Friedlander, Y
英文第一作者: Lemaitre, RN; King, IB; Kabagambe, EK; Wu, JHY; McKnight, B; Manichaikul, A; Guan, WH; Sun, Q; Chasman, DI; Foy, M; Wang, L; Zhu, JW; Siscovick, DS; Tsai, MY; Arnett, DK; Psaty, BM; Djousse, L; Chen, YDI; Tang, WH; Weng, LC; Wu, HY; Jensen, MK; Chu, AY; Jacobs, DR; Rich, SS; Mozaffarian, D; Steffen, L; Rimm, EB; Hu, FB; Ridker, PM; Fornage, M; Friedlander, Y
联系作者: Lemaitre, RN (reprint author), Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98119 USA.
英文联系作者: Lemaitre, RN (reprint author), Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98119 USA.
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发表年度: 2015
卷: 56
期: 1
页码: 176-184
摘要: Very long-chain saturated fatty acids (VLSFAs) are saturated fatty acids with 20 or more carbons. In contrast to the more abundant saturated fatty acids, such as palmitic acid, there is growing evidence that circulating VLSFAs may have beneficial biological properties. Whether genetic factors influence circulating levels of VLSFAs is not known. We investigated the association of common genetic variation with plasma phospholipid/erythrocyte levels of three VLSFAs by performing genome-wide association studies in seven population-based cohorts comprising 10,129 subjects of European ancestry. We observed associations of circulating VLSFA concentrations with common variants in two genes, serine palmitoyl-transferase long-chain base subunit 3 (SPTLC3), a gene involved in the rate-limiting step of de novo sphingolipid synthesis, and ceramide synthase 4 (CERS4). The SPTLC3 variant at rs680379 was associated with higher arachidic acid (20:0, P = 5.81 x 10(-13)). The CERS4 variant at rs2100944 was associated with higher levels of 20:0 (P = 2.65 x 10(-40)) and in analyses that adjusted for 20:0, with lower levels of behenic acid (P = 4.22 x 10(-26)) and lignoceric acid (P = 3.20 x 10(-21)). These novel associations suggest an inter-relationship of circulating VLSFAs and sphingolipid synthesis.
英文摘要: Very long-chain saturated fatty acids (VLSFAs) are saturated fatty acids with 20 or more carbons. In contrast to the more abundant saturated fatty acids, such as palmitic acid, there is growing evidence that circulating VLSFAs may have beneficial biological properties. Whether genetic factors influence circulating levels of VLSFAs is not known. We investigated the association of common genetic variation with plasma phospholipid/erythrocyte levels of three VLSFAs by performing genome-wide association studies in seven population-based cohorts comprising 10,129 subjects of European ancestry. We observed associations of circulating VLSFA concentrations with common variants in two genes, serine palmitoyl-transferase long-chain base subunit 3 (SPTLC3), a gene involved in the rate-limiting step of de novo sphingolipid synthesis, and ceramide synthase 4 (CERS4). The SPTLC3 variant at rs680379 was associated with higher arachidic acid (20:0, P = 5.81 x 10(-13)). The CERS4 variant at rs2100944 was associated with higher levels of 20:0 (P = 2.65 x 10(-40)) and in analyses that adjusted for 20:0, with lower levels of behenic acid (P = 4.22 x 10(-26)) and lignoceric acid (P = 3.20 x 10(-21)). These novel associations suggest an inter-relationship of circulating VLSFAs and sphingolipid synthesis.
刊物名称: JOURNAL OF LIPID RESEARCH
英文刊物名称: JOURNAL OF LIPID RESEARCH
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学科: Biochemistry & Molecular Biology
英文学科: Biochemistry & Molecular Biology
影响因子: 4.421
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论文类别: Article
英文论文类别: Article
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