论文库首页  论文库
 
论文编号:
论文题目: Conditional Deletion of Men1 in the Pancreatic beta-Cell Leads to Glucagon-Expressing Tumor Development
英文论文题目: Conditional Deletion of Men1 in the Pancreatic beta-Cell Leads to Glucagon-Expressing Tumor Development
第一作者: Li, F; Su, YT; Cheng, YL; Jiang, XL; Peng, Y; Li, YL; Lu, JL; Gu, YY; Zhang, CX; Cao, YN; Wang, WQ; Ning, G
英文第一作者: Li, F; Su, YT; Cheng, YL; Jiang, XL; Peng, Y; Li, YL; Lu, JL; Gu, YY; Zhang, CX; Cao, YN; Wang, WQ; Ning, G
联系作者: Cao, YN (reprint author), Shanghai Jiao Tong Univ, Sch Med, Dept Endocrinol & Metab, Shanghai Clin Ctr Endocrine & Metab Dis,Rui Jin H, 197 Rui Jin Second Rd, Shanghai 200025, Peoples R China.
英文联系作者: Cao, YN (reprint author), Shanghai Jiao Tong Univ, Sch Med, Dept Endocrinol & Metab, Shanghai Clin Ctr Endocrine & Metab Dis,Rui Jin H, 197 Rui Jin Second Rd, Shanghai 200025, Peoples R China.
外单位作者单位:
英文外单位作者单位:
发表年度: 2015
卷: 156
期: 1
页码: 48-57
摘要: The tumor suppressor menin is recognized as a key regulator of beta-cell proliferation. To induce tumorigenesis within the pancreatic beta-cells, floxed alleles of Men1 were selectively ablated using Cre-recombinase driven by the insulin promoter. Despite the beta-cell specificity of the RipCre, glucagon-expressing tumors as well as insulinomas developed in old mutant mice. These glucagon-expressing tumor cells were menin deficient and expressed the mature beta-cell-specific transcription factors Brain-specific homeobox POU domain protein 4 (Brn4) and v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (MafB). Moreover, the inactivation of beta-cell-specific transcription factors was observed in mutant beta-cells. Our work shows that Men1 ablation in the pancreatic beta-cells leads to the inactivation of specific transcription factors, resulting in glucagon-expressing tumor development, which sheds light on the mechanisms of islet tumorigenesis.
英文摘要: The tumor suppressor menin is recognized as a key regulator of beta-cell proliferation. To induce tumorigenesis within the pancreatic beta-cells, floxed alleles of Men1 were selectively ablated using Cre-recombinase driven by the insulin promoter. Despite the beta-cell specificity of the RipCre, glucagon-expressing tumors as well as insulinomas developed in old mutant mice. These glucagon-expressing tumor cells were menin deficient and expressed the mature beta-cell-specific transcription factors Brain-specific homeobox POU domain protein 4 (Brn4) and v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (MafB). Moreover, the inactivation of beta-cell-specific transcription factors was observed in mutant beta-cells. Our work shows that Men1 ablation in the pancreatic beta-cells leads to the inactivation of specific transcription factors, resulting in glucagon-expressing tumor development, which sheds light on the mechanisms of islet tumorigenesis.
刊物名称: ENDOCRINOLOGY
英文刊物名称: ENDOCRINOLOGY
论文全文:
英文论文全文:
全文链接:
其它备注:
英文其它备注:
学科: Endocrinology & Metabolism
英文学科: Endocrinology & Metabolism
影响因子: 4.503
第一作者所在部门:
英文第一作者所在部门:
论文出处:
英文论文出处:
论文类别: Article
英文论文类别: Article
参与作者:
英文参与作者:
 
2014 中国科学院上海生命科学研究院 版权所有