论文库首页  论文库
 
论文编号:
论文题目: miR-144/451 Promote Cell Proliferation via Targeting PTEN/AKT Pathway in Insulinomas
英文论文题目: miR-144/451 Promote Cell Proliferation via Targeting PTEN/AKT Pathway in Insulinomas
第一作者: Jiang, XL; Shan, AJ; Su, YT; Cheng, YL; Gu, WQ; Wang, WQ; Ning, G; Cao, YA
英文第一作者: Jiang, XL; Shan, AJ; Su, YT; Cheng, YL; Gu, WQ; Wang, WQ; Ning, G; Cao, YA
联系作者: Cao, YA (reprint author), Shanghai Jiao Tong Univ, Rui Jin Hosp, Shanghai Key Lab Endocrine Tumors, Shanghai Clin Ctr Endocrine & Metab Dis,Sch Med, Shanghai 200025, Peoples R China.
英文联系作者: Cao, YA (reprint author), Shanghai Jiao Tong Univ, Rui Jin Hosp, Shanghai Key Lab Endocrine Tumors, Shanghai Clin Ctr Endocrine & Metab Dis,Sch Med, Shanghai 200025, Peoples R China.
外单位作者单位:
英文外单位作者单位:
发表年度: 2015
卷: 156
期: 7
页码: 2429-2439
摘要: Insulinoma is the main type of functional pancreatic neuroendocrine tumors. The functional microRNAs ( miRNAs) regulating tumor growth and progression in insulinomas are still unknown. We conducted the miRNA expression profile analysis using miRNA quantitative RT-PCR array and identified 114 differentially expressed miRNAs in human insulinomas compared with normal pancreatic islets. Forty-one differentially expressed miRNAs belonged to 7 miRNA families, and 28 miRNAs in 3 of the families localized in the epigenetically regulated imprinted chromosome 14q32 region. We validated the most significant differentially expressed miRNA cluster miR-144/451 in another 8 human normal islet samples and 25 insulinomas. Our data showed that the overexpression of miR-144/451 in mouse pancreatic beta-cells promoted cell proliferation by targeting the beta-cell regulator phosphatase and tensin homolog deleted on chromosome ten/v-akt murine thymoma viral on cogene homolog pathway and cyclin-dependent kinase inhibitor 2D. Our findings highlight the importance of functional miRNAs in insulinomas.
英文摘要: Insulinoma is the main type of functional pancreatic neuroendocrine tumors. The functional microRNAs ( miRNAs) regulating tumor growth and progression in insulinomas are still unknown. We conducted the miRNA expression profile analysis using miRNA quantitative RT-PCR array and identified 114 differentially expressed miRNAs in human insulinomas compared with normal pancreatic islets. Forty-one differentially expressed miRNAs belonged to 7 miRNA families, and 28 miRNAs in 3 of the families localized in the epigenetically regulated imprinted chromosome 14q32 region. We validated the most significant differentially expressed miRNA cluster miR-144/451 in another 8 human normal islet samples and 25 insulinomas. Our data showed that the overexpression of miR-144/451 in mouse pancreatic beta-cells promoted cell proliferation by targeting the beta-cell regulator phosphatase and tensin homolog deleted on chromosome ten/v-akt murine thymoma viral on cogene homolog pathway and cyclin-dependent kinase inhibitor 2D. Our findings highlight the importance of functional miRNAs in insulinomas.
刊物名称: ENDOCRINOLOGY
英文刊物名称: ENDOCRINOLOGY
论文全文:
英文论文全文:
全文链接:
其它备注:
英文其它备注:
学科: Endocrinology & Metabolism
英文学科: Endocrinology & Metabolism
影响因子: 4.503
第一作者所在部门:
英文第一作者所在部门:
论文出处:
英文论文出处:
论文类别: Article
英文论文类别: Article
参与作者:
英文参与作者:
 
2014 中国科学院上海生命科学研究院 版权所有