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论文题目: Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5
英文论文题目: Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5
第一作者: Zhang, YL; Nguyen, T; Tang, P; Kennedy, NJ; Jiao, HP; Zhang, ML; Reynolds, JM; Jaeschke, A; Martin-Orozco, N; Chung, YS; He, WM; Wang, C; Jia, WP; Ge, BX; Davis, RJ; Fiavell, RA; Dong, C
英文第一作者: Zhang, YL; Nguyen, T; Tang, P; Kennedy, NJ; Jiao, HP; Zhang, ML; Reynolds, JM; Jaeschke, A; Martin-Orozco, N; Chung, YS; He, WM; Wang, C; Jia, WP; Ge, BX; Davis, RJ; Fiavell, RA; Dong, C
联系作者: Fiavell, RA (reprint author), Yale Univ, Howard Hughes Med Inst, Dept Immunol, New Haven, CT 06520 USA.
英文联系作者: Fiavell, RA (reprint author), Yale Univ, Howard Hughes Med Inst, Dept Immunol, New Haven, CT 06520 USA.
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发表年度: 2015
卷: 290
期: 24
页码: 14875-14883
摘要: Obesity and metabolic disorders such as insulin resistance and type 2 diabetes have become a major threat to public health globally. The mechanisms that lead to insulin resistance in type 2 diabetes have not been well understood. In this study, we show that mice deficient in MAPK phosphatase 5 (MKP5) develop insulin resistance spontaneously at an early stage of life and glucose intolerance at a later age. Increased macrophage infiltration in white adipose tissue of young MKP5-deficient mice correlates with the development of insulin resistance. Glucose intolerance in MKP5-deficient mice is accompanied by significantly increased visceral adipose weight, reduced AKT activation, enhanced p38 activity, and increased inflammation in visceral adipose tissue when compared with wild-type (WT) mice. Deficiency of MKP5 resulted in increased inflammatory activation in macrophages. These findings thus demonstrate that MKP5 critically controls inflammation in white adipose tissue and the development of metabolic disorders.
英文摘要: Obesity and metabolic disorders such as insulin resistance and type 2 diabetes have become a major threat to public health globally. The mechanisms that lead to insulin resistance in type 2 diabetes have not been well understood. In this study, we show that mice deficient in MAPK phosphatase 5 (MKP5) develop insulin resistance spontaneously at an early stage of life and glucose intolerance at a later age. Increased macrophage infiltration in white adipose tissue of young MKP5-deficient mice correlates with the development of insulin resistance. Glucose intolerance in MKP5-deficient mice is accompanied by significantly increased visceral adipose weight, reduced AKT activation, enhanced p38 activity, and increased inflammation in visceral adipose tissue when compared with wild-type (WT) mice. Deficiency of MKP5 resulted in increased inflammatory activation in macrophages. These findings thus demonstrate that MKP5 critically controls inflammation in white adipose tissue and the development of metabolic disorders.
刊物名称: JOURNAL OF BIOLOGICAL CHEMISTRY
英文刊物名称: JOURNAL OF BIOLOGICAL CHEMISTRY
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学科: Biochemistry & Molecular Biology
英文学科: Biochemistry & Molecular Biology
影响因子: 4.573
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论文类别: Article
英文论文类别: Article
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