论文库首页  论文库
 
论文编号:
论文题目: Inhibition of Transforming Growth Factor beta (TGF-beta) Signaling can Substitute for Oct4 Protein in Reprogramming and Maintain Pluripotency
英文论文题目: Inhibition of Transforming Growth Factor beta (TGF-beta) Signaling can Substitute for Oct4 Protein in Reprogramming and Maintain Pluripotency
第一作者: Tan, FZ; Qian, C; Tang, K; Abd-Allah, SM; Jing, NH
英文第一作者: Tan, FZ; Qian, C; Tang, K; Abd-Allah, SM; Jing, NH
联系作者: Jing, NH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.
英文联系作者: Jing, NH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.
外单位作者单位:
英文外单位作者单位:
发表年度: 2015
卷: 290
期: 7
页码: 4500-4511
摘要: Mouse pluripotent stem cells (PSCs), such as ES cells and induced PSCs (iPSCs), are an excellent system to investigate the molecular and cellular mechanisms involved in early embryonic development. The signaling pathways orchestrated by leukemia inhibitor factor/STAT3, Wnt/beta-catenin, and FGF/MEK/ERK play key roles in the generation of pluripotency. However, the function of TGF-beta signaling in this process remains elusive. Here we show that inhibiting TGF-beta signaling with its inhibitor SB431542 can substitute for Oct4 during reprogramming. Moreover, inhibiting TGF-beta signaling can sustain the pluripotency of iPSCs and ES cells through modulating FGF/MEK/ERK signaling. Therefore, this study reveals a novel function of TGF-beta signaling inhibition in the generation and maintenance of PSCs.
英文摘要: Mouse pluripotent stem cells (PSCs), such as ES cells and induced PSCs (iPSCs), are an excellent system to investigate the molecular and cellular mechanisms involved in early embryonic development. The signaling pathways orchestrated by leukemia inhibitor factor/STAT3, Wnt/beta-catenin, and FGF/MEK/ERK play key roles in the generation of pluripotency. However, the function of TGF-beta signaling in this process remains elusive. Here we show that inhibiting TGF-beta signaling with its inhibitor SB431542 can substitute for Oct4 during reprogramming. Moreover, inhibiting TGF-beta signaling can sustain the pluripotency of iPSCs and ES cells through modulating FGF/MEK/ERK signaling. Therefore, this study reveals a novel function of TGF-beta signaling inhibition in the generation and maintenance of PSCs.
刊物名称: JOURNAL OF BIOLOGICAL CHEMISTRY
英文刊物名称: JOURNAL OF BIOLOGICAL CHEMISTRY
论文全文:
英文论文全文:
全文链接:
其它备注:
英文其它备注:
学科: Biochemistry & Molecular Biology
英文学科: Biochemistry & Molecular Biology
影响因子: 4.573
第一作者所在部门:
英文第一作者所在部门:
论文出处:
英文论文出处:
论文类别: Article
英文论文类别: Article
参与作者:
英文参与作者:
 
2014 中国科学院上海生命科学研究院 版权所有