论文库首页  论文库
 
论文编号:
论文题目: Differential positive selection of malaria resistance genes in three indigenous populations of Peninsular Malaysia
英文论文题目: Differential positive selection of malaria resistance genes in three indigenous populations of Peninsular Malaysia
第一作者: Liu, XY; Yunus, Y; Lu, DS; Aghakhanian, F; Saw, WY; Deng, L; Ali, M; Wang, X; Ghazali, F; Rahman, TA; Shaari, SA; Salleh, MZ; Phipps, ME; Ong, RTH; Xu, SH; Teo, YY; Hoh, BP
英文第一作者: Liu, XY; Yunus, Y; Lu, DS; Aghakhanian, F; Saw, WY; Deng, L; Ali, M; Wang, X; Ghazali, F; Rahman, TA; Shaari, SA; Salleh, MZ; Phipps, ME; Ong, RTH; Xu, SH; Teo, YY; Hoh, BP
联系作者: Hoh, BP (reprint author), Univ Teknol MARA, Inst Med Mol Biotechnol, Fac Med, Sungai Buloh Campus,Jalan Hosp, Sungai Buloh 47000, Selangor, Malaysia.
英文联系作者: Hoh, BP (reprint author), Univ Teknol MARA, Inst Med Mol Biotechnol, Fac Med, Sungai Buloh Campus,Jalan Hosp, Sungai Buloh 47000, Selangor, Malaysia.
外单位作者单位:
英文外单位作者单位:
发表年度: 2015
卷: 134
期: 4
页码: 375-392
摘要: The indigenous populations from Peninsular Malaysia, locally known as Orang Asli, continue to adopt an agro-subsistence nomadic lifestyle, residing primarily within natural jungle habitats. Leading a hunter-gatherer lifestyle in a tropical jungle environment, the Orang Asli are routinely exposed to malaria. Here we surveyed the genetic architecture of individuals from four Orang Asli tribes with high-density genotyping across more than 2.5 million polymorphisms. These tribes reside in different geographical locations in Peninsular Malaysia and belong to three main ethno-linguistic groups, where there is minimal interaction between the tribes. We first dissect the genetic diversity and admixture between the tribes and with neighboring urban populations. Later, by implementing five metrics, we investigated the genome-wide signatures for positive natural selection of these Orang Asli, respectively. Finally, we searched for evidence of genomic adaptation to the pressure of malaria infection. We observed that different evolutionary responses might have emerged in the different Orang Asli communities to mitigate malaria infection.
英文摘要: The indigenous populations from Peninsular Malaysia, locally known as Orang Asli, continue to adopt an agro-subsistence nomadic lifestyle, residing primarily within natural jungle habitats. Leading a hunter-gatherer lifestyle in a tropical jungle environment, the Orang Asli are routinely exposed to malaria. Here we surveyed the genetic architecture of individuals from four Orang Asli tribes with high-density genotyping across more than 2.5 million polymorphisms. These tribes reside in different geographical locations in Peninsular Malaysia and belong to three main ethno-linguistic groups, where there is minimal interaction between the tribes. We first dissect the genetic diversity and admixture between the tribes and with neighboring urban populations. Later, by implementing five metrics, we investigated the genome-wide signatures for positive natural selection of these Orang Asli, respectively. Finally, we searched for evidence of genomic adaptation to the pressure of malaria infection. We observed that different evolutionary responses might have emerged in the different Orang Asli communities to mitigate malaria infection.
刊物名称: HUMAN GENETICS
英文刊物名称: HUMAN GENETICS
论文全文:
英文论文全文:
全文链接:
其它备注:
英文其它备注:
学科: Genetics & Heredity
英文学科: Genetics & Heredity
影响因子: 4.824
第一作者所在部门:
英文第一作者所在部门:
论文出处:
英文论文出处:
论文类别: Article
英文论文类别: Article
参与作者:
英文参与作者:
 
2014 中国科学院上海生命科学研究院 版权所有