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论文题目: Opioid receptor trafficking and interaction in nociceptors
英文论文题目: Opioid receptor trafficking and interaction in nociceptors
第一作者: Zhang, X; Bao, L; Li, S
英文第一作者: Zhang, X; Bao, L; Li, S
联系作者: Zhang, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.
英文联系作者: Zhang, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.
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发表年度: 2015
卷: 172
期: 2
页码: 364-374
摘要: Opiate analgesics such as morphine are often used for pain therapy. However, antinociceptive tolerance and dependence may develop with long-term use of these drugs. It was found that -opioid receptors can interact with -opioid receptors, and morphine antinociceptive tolerance can be reduced by blocking -opioid receptors. Recent studies have shown that - and -opioid receptors are co-expressed in a considerable number of small neurons in the dorsal root ganglion. The interaction of -opioid receptors with -opioid receptors in the nociceptive afferents is facilitated by the stimulus-induced cell-surface expression of -opioid receptors, and contributes to morphine tolerance. Further analysis of the molecular, cellular and neural circuit mechanisms that regulate the trafficking and interaction of opioid receptors and related signalling molecules in the pain pathway would help to elucidate the mechanism of opiate analgesia and improve pain therapy. Linked ArticlesThis article is part of a themed section on Opioids: New Pathways to Functional Selectivity. To view the other articles in this section visit
英文摘要: Opiate analgesics such as morphine are often used for pain therapy. However, antinociceptive tolerance and dependence may develop with long-term use of these drugs. It was found that -opioid receptors can interact with -opioid receptors, and morphine antinociceptive tolerance can be reduced by blocking -opioid receptors. Recent studies have shown that - and -opioid receptors are co-expressed in a considerable number of small neurons in the dorsal root ganglion. The interaction of -opioid receptors with -opioid receptors in the nociceptive afferents is facilitated by the stimulus-induced cell-surface expression of -opioid receptors, and contributes to morphine tolerance. Further analysis of the molecular, cellular and neural circuit mechanisms that regulate the trafficking and interaction of opioid receptors and related signalling molecules in the pain pathway would help to elucidate the mechanism of opiate analgesia and improve pain therapy. Linked ArticlesThis article is part of a themed section on Opioids: New Pathways to Functional Selectivity. To view the other articles in this section visit
刊物名称: BRITISH JOURNAL OF PHARMACOLOGY
英文刊物名称: BRITISH JOURNAL OF PHARMACOLOGY
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学科: Pharmacology & Pharmacy
英文学科: Pharmacology & Pharmacy
影响因子: 4.842
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论文类别: Review
英文论文类别: Review
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