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论文题目: CD24 Ala57Val polymorphism is associated with spontaneous viral clearance in the HCV-infected Chinese population
英文论文题目: CD24 Ala57Val polymorphism is associated with spontaneous viral clearance in the HCV-infected Chinese population
第一作者: Sun, HB; Pan, Y; Wu, RH; Lv, J; Chi, XM; Wang, XM; Tu, ZK; Zhong, J; Sun, B; Liu, Y; Jiang, J; Niu, JQ
英文第一作者: Sun, HB; Pan, Y; Wu, RH; Lv, J; Chi, XM; Wang, XM; Tu, ZK; Zhong, J; Sun, B; Liu, Y; Jiang, J; Niu, JQ
联系作者: Jiang, J (reprint author), Jilin Univ, Dept Clin Epidemiol, Hosp 1, 71 Xinmin St, Changchun 130021, Peoples R China.
英文联系作者: Jiang, J (reprint author), Jilin Univ, Dept Clin Epidemiol, Hosp 1, 71 Xinmin St, Changchun 130021, Peoples R China.
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发表年度: 2015
卷: 35
期: 3
页码: 786-794
摘要: Background & AimsHost immune response to hepatitis C virus (HCV) is a vital factor involved in both viral clearance and liver disease pathogenesis. CD24 plays an important role in inflammation and immune response and CD24 polymorphisms are associated with risk and progression of chronic hepatitis B virus infection. Our study evaluated whether CD24 polymorphisms affect HCV clearance. MethodsWe genotyped 544 chronic hepatitis C (CHC) patients, 78 spontaneous hepatitis C clearance (SHC) patients and 215 healthy controls for CD24 gene variants at positions -P534, P170, P1527 and IFNL3 rs12979860 by pyrosequencing. In CHC patients, 362 individuals were treated with a recombinant IFN-2b/ribavirin combination for 48weeks and were followed up for an additional 24weeks. Lymphocyte CD24 expression was analysed by flow cytometry. ResultsWe show that P170 CT and CT/TT genotypes were over-represented in the SHC group compared to CHC patients (62.8% vs. 47.2% and 75.6% vs. 60.3%, for respective polymorphisms). In multivariate logistic analysis, P170 (CD24 Ala57Val) polymorphism was an independent predictor of SHC (adjusted OR=2.11, 95%CI=1.19-3.73, P=0.010 for CT genotype; OR=2.01, 95%CI=1.15-3.49, P=0.014 for CT/TT genotype). No significant associations were found between the CD24 polymorphisms and treatment-induced viral clearance in log-rank analysis and Cox regression analysis. Patients with the CT/TT genotype had greater T-cell CD24 expression than patients with the CC genotype. ConclusionsOur findings suggest that CD24 Ala57Val polymorphism and associated variations in CD24 expression may be an important predictor for SHC, but have no effect on antiviral drug treatment response in Chinese CHC patients.
英文摘要: Background & AimsHost immune response to hepatitis C virus (HCV) is a vital factor involved in both viral clearance and liver disease pathogenesis. CD24 plays an important role in inflammation and immune response and CD24 polymorphisms are associated with risk and progression of chronic hepatitis B virus infection. Our study evaluated whether CD24 polymorphisms affect HCV clearance. MethodsWe genotyped 544 chronic hepatitis C (CHC) patients, 78 spontaneous hepatitis C clearance (SHC) patients and 215 healthy controls for CD24 gene variants at positions -P534, P170, P1527 and IFNL3 rs12979860 by pyrosequencing. In CHC patients, 362 individuals were treated with a recombinant IFN-2b/ribavirin combination for 48weeks and were followed up for an additional 24weeks. Lymphocyte CD24 expression was analysed by flow cytometry. ResultsWe show that P170 CT and CT/TT genotypes were over-represented in the SHC group compared to CHC patients (62.8% vs. 47.2% and 75.6% vs. 60.3%, for respective polymorphisms). In multivariate logistic analysis, P170 (CD24 Ala57Val) polymorphism was an independent predictor of SHC (adjusted OR=2.11, 95%CI=1.19-3.73, P=0.010 for CT genotype; OR=2.01, 95%CI=1.15-3.49, P=0.014 for CT/TT genotype). No significant associations were found between the CD24 polymorphisms and treatment-induced viral clearance in log-rank analysis and Cox regression analysis. Patients with the CT/TT genotype had greater T-cell CD24 expression than patients with the CC genotype. ConclusionsOur findings suggest that CD24 Ala57Val polymorphism and associated variations in CD24 expression may be an important predictor for SHC, but have no effect on antiviral drug treatment response in Chinese CHC patients.
刊物名称: LIVER INTERNATIONAL
英文刊物名称: LIVER INTERNATIONAL
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学科: Gastroenterology & Hepatology
英文学科: Gastroenterology & Hepatology
影响因子: 4.85
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论文类别: Article
英文论文类别: Article
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