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论文题目: Vibsanin B Preferentially Targets HSP90b, Inhibits Interstitial Leukocyte Migration, and Ameliorates Experimental Autoimmune Encephalomyelitis
英文论文题目: Vibsanin B Preferentially Targets HSP90b, Inhibits Interstitial Leukocyte Migration, and Ameliorates Experimental Autoimmune Encephalomyelitis
第一作者: Ye, BX; Deng, X; Shao, LD; Lu, Y; Xiao, R; Liu, YJ; Jin, Y; Xie, YY; Zhao, Y; Luo, LF; Ma, S; Gao, M; Zhang, LR; He, J; Zhang, WN; Chen, Y; Xia, CF; Deng, M; Liu, TX; Zhao, QS; Chen, SJ; Chen, Z
英文第一作者: Ye, BX; Deng, X; Shao, LD; Lu, Y; Xiao, R; Liu, YJ; Jin, Y; Xie, YY; Zhao, Y; Luo, LF; Ma, S; Gao, M; Zhang, LR; He, J; Zhang, WN; Chen, Y; Xia, CF; Deng, M; Liu, TX; Zhao, QS; Chen, SJ; Chen, Z
联系作者: Chen, Z (reprint author), Shanghai Jiao Tong Univ, RuiJin Hosp, Sch Med, 197 Rui Jin Rd 2, Shanghai 200025, Peoples R China.
英文联系作者: Chen, Z (reprint author), Shanghai Jiao Tong Univ, RuiJin Hosp, Sch Med, 197 Rui Jin Rd 2, Shanghai 200025, Peoples R China.
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发表年度: 2015
卷: 194
期: 9
页码: 4489-4497
摘要: Interstitial leukocyte migration plays a critical role in inflammation and offers a therapeutic target for treating inflammation-associated diseases such as multiple sclerosis. Identifying small molecules to inhibit undesired leukocyte migration provides promise for the treatment of these disorders. In this study, we identified vibsanin B, a novel macrocyclic diterpenoid isolated from Viburnum odoratissimum Ker-Gawl, that inhibited zebrafish interstitial leukocyte migration using a transgenic zebrafish line (TG:zlyz-enhanced GFP). We found that vibsanin B preferentially binds to heat shock protein (HSP)90b. At the molecular level, inactivation of HSP90 can mimic vibsanin B's effect of inhibiting interstitial leukocyte migration. Furthermore, we demonstrated that vibsanin B ameliorates experimental autoimmune encephalomyelitis in mice with pathological manifestation of decreased leukocyte infiltration into their CNS. In summary, vibsanin B is a novel lead compound that preferentially targets HSP90 beta and inhibits interstitial leukocyte migration, offering a promising drug lead for treating inflammation-associated diseases.
英文摘要: Interstitial leukocyte migration plays a critical role in inflammation and offers a therapeutic target for treating inflammation-associated diseases such as multiple sclerosis. Identifying small molecules to inhibit undesired leukocyte migration provides promise for the treatment of these disorders. In this study, we identified vibsanin B, a novel macrocyclic diterpenoid isolated from Viburnum odoratissimum Ker-Gawl, that inhibited zebrafish interstitial leukocyte migration using a transgenic zebrafish line (TG:zlyz-enhanced GFP). We found that vibsanin B preferentially binds to heat shock protein (HSP)90b. At the molecular level, inactivation of HSP90 can mimic vibsanin B's effect of inhibiting interstitial leukocyte migration. Furthermore, we demonstrated that vibsanin B ameliorates experimental autoimmune encephalomyelitis in mice with pathological manifestation of decreased leukocyte infiltration into their CNS. In summary, vibsanin B is a novel lead compound that preferentially targets HSP90 beta and inhibits interstitial leukocyte migration, offering a promising drug lead for treating inflammation-associated diseases.
刊物名称: JOURNAL OF IMMUNOLOGY
英文刊物名称: JOURNAL OF IMMUNOLOGY
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学科: Immunology
英文学科: Immunology
影响因子: 4.922
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论文类别: Article
英文论文类别: Article
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