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论文题目: Fstl1 Promotes Asthmatic Airway Remodeling by Inducing Oncostatin M
英文论文题目: Fstl1 Promotes Asthmatic Airway Remodeling by Inducing Oncostatin M
第一作者: Miller, M; Beppu, A; Rosenthal, P; Pham, A; Das, S; Karta, M; Song, DJ; Vuong, C; Doherty, T; Croft, M; Zuraw, B; Zhang, X; Gao, X; Aceves, S; Chouiali, F; Hamid, Q; Broide, DH
英文第一作者: Miller, M; Beppu, A; Rosenthal, P; Pham, A; Das, S; Karta, M; Song, DJ; Vuong, C; Doherty, T; Croft, M; Zuraw, B; Zhang, X; Gao, X; Aceves, S; Chouiali, F; Hamid, Q; Broide, DH
联系作者: Broide, DH (reprint author), Univ Calif San Diego, Dept Med, Biomed Sci Bldg,Room 5090,9500 Gilman Dr, La Jolla, CA 92093 USA.
英文联系作者: Broide, DH (reprint author), Univ Calif San Diego, Dept Med, Biomed Sci Bldg,Room 5090,9500 Gilman Dr, La Jolla, CA 92093 USA.
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发表年度: 2015
卷: 195
期: 8
页码: 3546-3556
摘要: Chronic asthma is associated with airway remodeling and decline in lung function. In this article, we show that follistatin-like 1 (Fstl1), a mediator not previously associated with asthma, is highly expressed by macrophages in the lungs of humans with severe asthma. Chronic allergen-challenged Lys-Cre(tg) /Fstl1(Delta/Delta) mice in whom Fstl1 is inactivated in macrophages/myeloid cells had significantly reduced airway remodeling and reduced levels of oncostatin M (OSM), a cytokine previously not known to be regulated by Fstl1. The importance of the Fstl1 induction of OSM to airway remodeling was demonstrated in murine studies in which administration of Fstl1 induced airway remodeling and increased OSM, whereas administration of an anti-OSM Ab blocked the effect of Fstl1 on inducing airway remodeling, eosinophilic airway inflammation, and airway hyperresponsiveness, all cardinal features of asthma. Overall, these studies demonstrate that the Fstl1/OSM pathway may be a novel pathway to inhibit airway remodeling in severe human asthma.
英文摘要: Chronic asthma is associated with airway remodeling and decline in lung function. In this article, we show that follistatin-like 1 (Fstl1), a mediator not previously associated with asthma, is highly expressed by macrophages in the lungs of humans with severe asthma. Chronic allergen-challenged Lys-Cre(tg) /Fstl1(Delta/Delta) mice in whom Fstl1 is inactivated in macrophages/myeloid cells had significantly reduced airway remodeling and reduced levels of oncostatin M (OSM), a cytokine previously not known to be regulated by Fstl1. The importance of the Fstl1 induction of OSM to airway remodeling was demonstrated in murine studies in which administration of Fstl1 induced airway remodeling and increased OSM, whereas administration of an anti-OSM Ab blocked the effect of Fstl1 on inducing airway remodeling, eosinophilic airway inflammation, and airway hyperresponsiveness, all cardinal features of asthma. Overall, these studies demonstrate that the Fstl1/OSM pathway may be a novel pathway to inhibit airway remodeling in severe human asthma.
刊物名称: JOURNAL OF IMMUNOLOGY
英文刊物名称: JOURNAL OF IMMUNOLOGY
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学科: Immunology
英文学科: Immunology
影响因子: 4.922
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论文类别: Article
英文论文类别: Article
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