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论文题目: Regulation of circRNA biogenesis
英文论文题目: Regulation of circRNA biogenesis
第一作者: Chen, LL; Yang, L
英文第一作者: Chen, LL; Yang, L
联系作者: Chen, LL (reprint author), Chinese Acad Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai, Peoples R China.
英文联系作者: Chen, LL (reprint author), Chinese Acad Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai, Peoples R China.
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发表年度: 2015
卷: 12
期: 4
页码: 381-388
摘要: Unlike linear RNAs terminated with 5 caps and 3 tails, circular RNAs are characterized by covalently closed loop structures with neither 5 to 3 polarity nor polyadenylated tail. This intrinsic characteristic has led to the general under-estimation of the existence of circular RNAs in previous polyadenylated transcriptome analyses. With the advent of specific biochemical and computational approaches, a large number of circular RNAs from back-spliced exons (circRNAs) have been identified in various cell lines and across different species. Recent studies have uncovered that back-splicing requires canonical spliceosomal machinery and can be facilitated by both complementary sequences and specific protein factors. In this review, we highlight our current understanding of the regulation of circRNA biogenesis, including both the competition between splicing and back-splicing and the previously under-appreciated alternative circularization.
英文摘要: Unlike linear RNAs terminated with 5 caps and 3 tails, circular RNAs are characterized by covalently closed loop structures with neither 5 to 3 polarity nor polyadenylated tail. This intrinsic characteristic has led to the general under-estimation of the existence of circular RNAs in previous polyadenylated transcriptome analyses. With the advent of specific biochemical and computational approaches, a large number of circular RNAs from back-spliced exons (circRNAs) have been identified in various cell lines and across different species. Recent studies have uncovered that back-splicing requires canonical spliceosomal machinery and can be facilitated by both complementary sequences and specific protein factors. In this review, we highlight our current understanding of the regulation of circRNA biogenesis, including both the competition between splicing and back-splicing and the previously under-appreciated alternative circularization.
刊物名称: RNA BIOLOGY
英文刊物名称: RNA BIOLOGY
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学科: Biochemistry & Molecular Biology
英文学科: Biochemistry & Molecular Biology
影响因子: 4.974
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论文类别: Article
英文论文类别: Article
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