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论文题目: DNA methylation pathways and their crosstalk with histone methylation
英文论文题目: DNA methylation pathways and their crosstalk with histone methylation
第一作者: Du, JM; Johnson, LM; Jacobsen, SE; Patel, DJ
英文第一作者: Du, JM; Johnson, LM; Jacobsen, SE; Patel, DJ
联系作者: Jacobsen, SE (reprint author), Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA.
英文联系作者: Jacobsen, SE (reprint author), Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA.
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发表年度: 2015
卷: 16
期: 9
页码: 519-532
摘要: Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be established at specific regions of the genome and then maintained at these sites through cell division. Protein structural domains that specifically recognize methylated DNA and methylated histones are key for targeting enzymes that catalyse these marks to appropriate genome sites. Genetic, genomic, structural and biochemical data reveal connections between these two epigenetic marks, and these domains mediate much of the crosstalk.
英文摘要: Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be established at specific regions of the genome and then maintained at these sites through cell division. Protein structural domains that specifically recognize methylated DNA and methylated histones are key for targeting enzymes that catalyse these marks to appropriate genome sites. Genetic, genomic, structural and biochemical data reveal connections between these two epigenetic marks, and these domains mediate much of the crosstalk.
刊物名称: NATURE REVIEWS MOLECULAR CELL BIOLOGY
英文刊物名称: NATURE REVIEWS MOLECULAR CELL BIOLOGY
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学科: Cell Biology
英文学科: Cell Biology
影响因子: 37.806
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论文类别: Review
英文论文类别: Review
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