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论文题目: Identification of multipotent mammary stemcells by protein C receptor expression
英文论文题目: Identification of multipotent mammary stemcells by protein C receptor expression
第一作者: Wang, DS; Cai, CG; Dong, XB; Yu, QC; Zhang, XO; Yang, L; Zeng, YA
英文第一作者: Wang, DS; Cai, CG; Dong, XB; Yu, QC; Zhang, XO; Yang, L; Zeng, YA
联系作者: Zeng, YA (reprint author), Chinese Acad Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.
英文联系作者: Zeng, YA (reprint author), Chinese Acad Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.
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发表年度: 2015
卷: 517
期: 7532
页码: 81-U201
摘要: The mammary gland is composed of multiple types of epithelial cells, which are generated by mammary stem cells (MaSCs) residing at the top of the hierarchy(1,2). However, the existence of these multi-potent MaSCs remains controversial and the nature of such cells is unknown(3,4). Here we demonstrate that protein C receptor (Procr), a novel Wnt target in the mammary gland, marks a unique population of multipotent mouse MaSCs. Procr-positive cells localize to the basal layer, exhibit epithelial-to-mesenchymal transition characteristics, and express low levels of basal keratins. Procr-expressing cells have a high regenerative capacity in transplantation assays and differentiate into all lineages of the mammary epithelium by lineage tracing. These results define a novel multipotent mammary stem cell population that could be important in the initiation of breast cancer.
英文摘要: The mammary gland is composed of multiple types of epithelial cells, which are generated by mammary stem cells (MaSCs) residing at the top of the hierarchy(1,2). However, the existence of these multi-potent MaSCs remains controversial and the nature of such cells is unknown(3,4). Here we demonstrate that protein C receptor (Procr), a novel Wnt target in the mammary gland, marks a unique population of multipotent mouse MaSCs. Procr-positive cells localize to the basal layer, exhibit epithelial-to-mesenchymal transition characteristics, and express low levels of basal keratins. Procr-expressing cells have a high regenerative capacity in transplantation assays and differentiate into all lineages of the mammary epithelium by lineage tracing. These results define a novel multipotent mammary stem cell population that could be important in the initiation of breast cancer.
刊物名称: NATURE
英文刊物名称: NATURE
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学科: Science & Technology - Other Topics
英文学科: Science & Technology - Other Topics
影响因子: 41.456
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论文类别: Article
英文论文类别: Article
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