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论文题目: Nickel exposure and prevalent albuminuria and beta 2-microglobulinuria: evidence from a population-based study
英文论文题目: Nickel exposure and prevalent albuminuria and beta 2-microglobulinuria: evidence from a population-based study
第一作者: Liu, G; Sun, Q; Zhu, MJ; Sun, L; Wang, ZZ; Li, HX; Li, Z; Chen, Y; Yin, HY; Lin, X
英文第一作者: Liu, G; Sun, Q; Zhu, MJ; Sun, L; Wang, ZZ; Li, HX; Li, Z; Chen, Y; Yin, HY; Lin, X
联系作者: Yin, HY; Lin, X (reprint author), Chinese Acad Sci, Inst Nutr Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.
英文联系作者: Yin, HY; Lin, X (reprint author), Chinese Acad Sci, Inst Nutr Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.
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发表年度: 2016
卷: 70
期: 5
页码: 437-443
摘要: Background High exposure to nickel could induce renal dysfunction in rodents and occupational workers. However, little is known about the effects of nonoccupational exposure to nickel on renal health in the general population. We aimed to examine the associations of urinary nickel concentrations with albuminuria and beta 2-microglobulinuria in Chinese adults. Methods 2115 non-institutionalised Chinese men and women aged 55-76 years from Beijing and Shanghai were included. Urinary nickel concentrations were assessed by inductively coupled plasma mass spectroscopy. Plasma uric acid, urea nitrogen, C reactive protein and urinary albumin, beta 2-microglobulin and creatinine were measured. Albuminuria was defined as urinary albumin >= 30 mg/g creatinine, and beta 2-microglobulinuria was defined as urinary beta 2-microglobulin >= 200 mu g/g creatinine. Results Median concentration of urinary nickel was 3.95 mu g/g creatinine (IQR: 2.57-6.71 mu g/g creatinine), and prevalence of albuminuria, beta 2-microglobulinuria and both albuminuria and beta 2-microglobulinuria was 22.1%, 24.5% and 9.7%, respectively. Comparing the highest with the lowest quartile of urinary nickel, the ORs (95% CIs) were 1.99 (1.46 to 2.78) for albuminuria, 1.44 (1.07 to 1.95) for beta 2-microglobulinuria, and 2.95 (1.74 to 4.97) for both albuminuria and beta 2-microglobulinuria, after adjustment for demographic characteristics, lifestyle behaviours, body mass index, hypertension and diabetes. The association remained significant when further controlling for inflammatory markers or other heavy metals (all p trend <0.05). Conclusions This study suggested that urinary nickel levels were positively associated with albuminuria and beta 2-microglobulinuria in Chinese men and women, who had relatively low background nickel exposure. More prospective studies are needed to confirm our findings.
英文摘要: Background High exposure to nickel could induce renal dysfunction in rodents and occupational workers. However, little is known about the effects of nonoccupational exposure to nickel on renal health in the general population. We aimed to examine the associations of urinary nickel concentrations with albuminuria and beta 2-microglobulinuria in Chinese adults. Methods 2115 non-institutionalised Chinese men and women aged 55-76 years from Beijing and Shanghai were included. Urinary nickel concentrations were assessed by inductively coupled plasma mass spectroscopy. Plasma uric acid, urea nitrogen, C reactive protein and urinary albumin, beta 2-microglobulin and creatinine were measured. Albuminuria was defined as urinary albumin >= 30 mg/g creatinine, and beta 2-microglobulinuria was defined as urinary beta 2-microglobulin >= 200 mu g/g creatinine. Results Median concentration of urinary nickel was 3.95 mu g/g creatinine (IQR: 2.57-6.71 mu g/g creatinine), and prevalence of albuminuria, beta 2-microglobulinuria and both albuminuria and beta 2-microglobulinuria was 22.1%, 24.5% and 9.7%, respectively. Comparing the highest with the lowest quartile of urinary nickel, the ORs (95% CIs) were 1.99 (1.46 to 2.78) for albuminuria, 1.44 (1.07 to 1.95) for beta 2-microglobulinuria, and 2.95 (1.74 to 4.97) for both albuminuria and beta 2-microglobulinuria, after adjustment for demographic characteristics, lifestyle behaviours, body mass index, hypertension and diabetes. The association remained significant when further controlling for inflammatory markers or other heavy metals (all p trend <0.05). Conclusions This study suggested that urinary nickel levels were positively associated with albuminuria and beta 2-microglobulinuria in Chinese men and women, who had relatively low background nickel exposure. More prospective studies are needed to confirm our findings.
刊物名称: JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
英文刊物名称: JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
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学科: Public, Environmental & Occupational Health
英文学科: Public, Environmental & Occupational Health
影响因子: 3.608
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论文类别: Article
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