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论文题目: Evidence for the role of transposons in the recruitment of cis-regulatory motifs during the evolution of C4 photosynthesis
英文论文题目: Evidence for the role of transposons in the recruitment of cis-regulatory motifs during the evolution of C4 photosynthesis
第一作者: Cao, CS; Xu, JJ; Zheng, GY; Zhu, XG
英文第一作者: Cao, CS; Xu, JJ; Zheng, GY; Zhu, XG
联系作者: Zhu, XG (reprint author), Chinese Acad Sci, CAS Key Lab Computat Biol, CAS MPG Partner Inst Computat Biol, Room 102,Physiol Bldg,320 Yueyang Rd, Shanghai 200031, Peoples R China.
英文联系作者: Zhu, XG (reprint author), Chinese Acad Sci, CAS Key Lab Computat Biol, CAS MPG Partner Inst Computat Biol, Room 102,Physiol Bldg,320 Yueyang Rd, Shanghai 200031, Peoples R China.
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发表年度: 2016
卷: 17
期:
页码: 201
摘要: Background: C-4 photosynthesis evolved from C-3 photosynthesis and has higher light, water, and nitrogen use efficiencies. Several C-4 photosynthesis genes show cell-specific expression patterns, which are required for these high resource-use efficiencies. However, the mechanisms underlying the evolution of cis-regulatory elements that control these cell-specific expression patterns remain elusive. Results: In the present study, we tested the hypothesis that the cis-regulatory motifs related to C-4 photosynthesis genes were recruited from non-photosynthetic genes and further examined potential mechanisms facilitating this recruitment. We examined 65 predicted bundle sheath cell-specific motifs, 17 experimentally validated cell-specific cis-regulatory elements, and 1,034 motifs derived from gene regulatory networks. Approximately 7, 5, and 1,000 of these three categories of motifs, respectively, were apparently recruited during the evolution of C-4 photosynthesis. In addition, we checked 1) the distance between the acceptors and the donors of potentially recruited motifs in a chromosome, and 2) whether the potentially recruited motifs reside within the overlapping region of transposable elements and the promoter of donor genes. The results showed that 7, 4, and 658 of the potentially recruited motifs might have moved via the transposable elements. Furthermore, the potentially recruited motifs showed higher binding affinity to transcription factors compared to randomly generated sequences of the same length as the motifs. Conclusions: This study provides molecular evidence supporting the hypothesis that transposon-driven recruitment of pre-existing cis-regulatory elements from non-photosynthetic genes into photosynthetic genes plays an important role during C-4 evolution. The findings of the present study coincide with the observed repetitive emergence of C-4 during evolution.
英文摘要: Background: C-4 photosynthesis evolved from C-3 photosynthesis and has higher light, water, and nitrogen use efficiencies. Several C-4 photosynthesis genes show cell-specific expression patterns, which are required for these high resource-use efficiencies. However, the mechanisms underlying the evolution of cis-regulatory elements that control these cell-specific expression patterns remain elusive. Results: In the present study, we tested the hypothesis that the cis-regulatory motifs related to C-4 photosynthesis genes were recruited from non-photosynthetic genes and further examined potential mechanisms facilitating this recruitment. We examined 65 predicted bundle sheath cell-specific motifs, 17 experimentally validated cell-specific cis-regulatory elements, and 1,034 motifs derived from gene regulatory networks. Approximately 7, 5, and 1,000 of these three categories of motifs, respectively, were apparently recruited during the evolution of C-4 photosynthesis. In addition, we checked 1) the distance between the acceptors and the donors of potentially recruited motifs in a chromosome, and 2) whether the potentially recruited motifs reside within the overlapping region of transposable elements and the promoter of donor genes. The results showed that 7, 4, and 658 of the potentially recruited motifs might have moved via the transposable elements. Furthermore, the potentially recruited motifs showed higher binding affinity to transcription factors compared to randomly generated sequences of the same length as the motifs. Conclusions: This study provides molecular evidence supporting the hypothesis that transposon-driven recruitment of pre-existing cis-regulatory elements from non-photosynthetic genes into photosynthetic genes plays an important role during C-4 evolution. The findings of the present study coincide with the observed repetitive emergence of C-4 during evolution.
刊物名称: BMC GENOMICS
英文刊物名称: BMC GENOMICS
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学科: Biotechnology & Applied Microbiology; Genetics & Heredity
英文学科: Biotechnology & Applied Microbiology; Genetics & Heredity
影响因子: 3.729
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论文类别: Article
英文论文类别: Article
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