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论文题目:	Association Between the Change in Body Mass Index from Early Adulthood to Midlife and Subsequent Type 2 Diabetes Mellitus
英文论文题目:	Association Between the Change in Body Mass Index from Early Adulthood to Midlife and Subsequent Type 2 Diabetes Mellitus
第一作者:	Sun, WW; Shi, LX; Ye, Z; Mu, YM; Liu, C; Zhao, JJ; Chen, LL; Li, Q; Yang, T; Yan, L; Wan, Q; Wu, SL; Liu, Y; Wang, GX; Luo, ZJ; Tang, XL; Chen, G; Huo, YN; Gao, ZN; Su, Q; Wang, YM; Qin, GJ; Deng, HC; Yu, XF; Shen, FX; Chen, L; Zhao, LB; Sun, JC; Ding, L; Xu, Y; Xu, M; Dai, M; Wang, TG; Zhang, D; Lu, JL; Bi, YF; Lai, SH; Li, DH; Wang, WQ; Ning, G
英文第一作者:	Sun, WW; Shi, LX; Ye, Z; Mu, YM; Liu, C; Zhao, JJ; Chen, LL; Li, Q; Yang, T; Yan, L; Wan, Q; Wu, SL; Liu, Y; Wang, GX; Luo, ZJ; Tang, XL; Chen, G; Huo, YN; Gao, ZN; Su, Q; Wang, YM; Qin, GJ; Deng, HC; Yu, XF; Shen, FX; Chen, L; Zhao, LB; Sun, JC; Ding, L; Xu, Y; Xu, M; Dai, M; Wang, TG; Zhang, D; Lu, JL; Bi, YF; Lai, SH; Li, DH; Wang, WQ; Ning, G
联系作者:	Wang, WQ (reprint author), Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Natl Clin Res Ctr Metab Dis, Shanghai 200030, Peoples R China.
英文联系作者:	Wang, WQ (reprint author), Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Natl Clin Res Ctr Metab Dis, Shanghai 200030, Peoples R China.
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发表年度:	2016
卷:	24
期:	3
页码:	703-709
摘要:	Objective: To clarify the quantitative relationship of body mass index (BMI) change from early adulthood to midlife with presence of type 2 diabetes mellitus (T2DM) after midlife. Methods: This study included 120,666 middle-aged and elderly, whose retrospectively self-reported body weight at 20 and 40 years and measured height were available. BMI at 20 and 40 years and BMI change in between were defined as early-adulthood BMI, midlife BMI, and early-adulthood BMI change. Results: The odds ratio (OR) for T2DM associated with an 1-unit increment of early-adulthood or midlife BMI was 1.08 (95% confidence interval (CI), 1.07-1.08) and 1.09 (95% CI, 1.09-1.10) respectively. In the cross-tabulation of both early-adulthood BMI and BMI change, the prevalence of T2DM increased across both variables. Compared with participants with normal early-adulthood weight and BMI increase/decrease <= 1, the OR (95% CI) for T2DM of participants with early-adulthood overweight/obesity and BMI increase >= 4 kg/m(2) was 3.49 (3.05-4.00). For participants with early-adulthood underweight and BMI increase/decrease <= 1, the OR (95% CI) was 0.85 (0.75-0.97). Subgroup analysis according to sex and age showed similar trends. Conclusions: Early-adulthood BMI may influence T2DM prevalence after midlife independent of current BMI. T2DM prevalence after midlife was positively associated with early-adulthood weight gain and inversely related to early-adulthood weight loss, while early-adulthood weight loss could not completely negate the adverse effect of early-adulthood overweight/obesity on diabetes.
英文摘要:	Objective: To clarify the quantitative relationship of body mass index (BMI) change from early adulthood to midlife with presence of type 2 diabetes mellitus (T2DM) after midlife. Methods: This study included 120,666 middle-aged and elderly, whose retrospectively self-reported body weight at 20 and 40 years and measured height were available. BMI at 20 and 40 years and BMI change in between were defined as early-adulthood BMI, midlife BMI, and early-adulthood BMI change. Results: The odds ratio (OR) for T2DM associated with an 1-unit increment of early-adulthood or midlife BMI was 1.08 (95% confidence interval (CI), 1.07-1.08) and 1.09 (95% CI, 1.09-1.10) respectively. In the cross-tabulation of both early-adulthood BMI and BMI change, the prevalence of T2DM increased across both variables. Compared with participants with normal early-adulthood weight and BMI increase/decrease <= 1, the OR (95% CI) for T2DM of participants with early-adulthood overweight/obesity and BMI increase >= 4 kg/m(2) was 3.49 (3.05-4.00). For participants with early-adulthood underweight and BMI increase/decrease <= 1, the OR (95% CI) was 0.85 (0.75-0.97). Subgroup analysis according to sex and age showed similar trends. Conclusions: Early-adulthood BMI may influence T2DM prevalence after midlife independent of current BMI. T2DM prevalence after midlife was positively associated with early-adulthood weight gain and inversely related to early-adulthood weight loss, while early-adulthood weight loss could not completely negate the adverse effect of early-adulthood overweight/obesity on diabetes.
刊物名称:	OBESITY
英文刊物名称:	OBESITY
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学科:	Endocrinology & Metabolism; Nutrition & Dietetics
英文学科:	Endocrinology & Metabolism; Nutrition & Dietetics
影响因子:	3.873
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论文类别:	Article
英文论文类别:	Article
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