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论文题目: Changes in snoRNA and snRNA Abundance in the Human, Chimpanzee, Macaque, and Mouse Brain
英文论文题目: Changes in snoRNA and snRNA Abundance in the Human, Chimpanzee, Macaque, and Mouse Brain
第一作者: Zhang, B; Han, DD; Korostelev, Y; Yan, Z; Shao, NY; Khrameeva, E; Velichkovsky, BM; Chen, YPP; Gelfand, MS; Khaitovich, P
英文第一作者: Zhang, B; Han, DD; Korostelev, Y; Yan, Z; Shao, NY; Khrameeva, E; Velichkovsky, BM; Chen, YPP; Gelfand, MS; Khaitovich, P
联系作者: Khaitovich, P (reprint author), CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol, Shanghai, Peoples R China.
英文联系作者: Khaitovich, P (reprint author), CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol, Shanghai, Peoples R China.
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发表年度: 2016
卷: 8
期: 3
页码: 840-850
摘要: Small nuclear and nucleolar RNAs (snRNAs and snoRNAs) are known to be functionally and evolutionarily conserved elements of transcript processing machinery. Here, we investigated the expression evolution of snRNAs and snoRNAs by measuring their abundance in the frontal cortex of humans, chimpanzees, rhesus monkeys, and mice. Although snRNA expression is largely conserved, 44% of the 185measured snoRNA and 40% of the 134 snoRNA families showed significant expression divergence among species. The snRNA and snoRNA expression divergence included drastic changes unique to humans: A 10-fold elevated expression of U1 snRNAand a 1,000-fold drop in expression ofSNORA29. The decreased expression of SNORA29 might be due to twomutations that affect secondary structure stability. Using in situ hybridization, we further localized SNORA29 expression to nucleolar regions of neuronal cells. Our study presents the first observation of snoRNA abundance changes specific to the human lineage and suggests a possible mechanism underlying these changes.
英文摘要: Small nuclear and nucleolar RNAs (snRNAs and snoRNAs) are known to be functionally and evolutionarily conserved elements of transcript processing machinery. Here, we investigated the expression evolution of snRNAs and snoRNAs by measuring their abundance in the frontal cortex of humans, chimpanzees, rhesus monkeys, and mice. Although snRNA expression is largely conserved, 44% of the 185measured snoRNA and 40% of the 134 snoRNA families showed significant expression divergence among species. The snRNA and snoRNA expression divergence included drastic changes unique to humans: A 10-fold elevated expression of U1 snRNAand a 1,000-fold drop in expression ofSNORA29. The decreased expression of SNORA29 might be due to twomutations that affect secondary structure stability. Using in situ hybridization, we further localized SNORA29 expression to nucleolar regions of neuronal cells. Our study presents the first observation of snoRNA abundance changes specific to the human lineage and suggests a possible mechanism underlying these changes.
刊物名称: GENOME BIOLOGY AND EVOLUTION
英文刊物名称: GENOME BIOLOGY AND EVOLUTION
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学科: Evolutionary Biology; Genetics & Heredity
英文学科: Evolutionary Biology; Genetics & Heredity
影响因子: 3.979
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论文类别: Article
英文论文类别: Article
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