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论文题目: Systemic Wound Healing Associated with local sub-Cutaneous Mechanical Stimulation
英文论文题目: Systemic Wound Healing Associated with local sub-Cutaneous Mechanical Stimulation
第一作者: Nardini, C; Devescovi, V; Liu, YH; Zhou, XY; Lu, YT; Dent, JE
英文第一作者: Nardini, C; Devescovi, V; Liu, YH; Zhou, XY; Lu, YT; Dent, JE
联系作者: Nardini, C (reprint author), Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Grp Clin Genom Networks, Key Lab Computat Biol, Shanghai 200031, Peoples R China.
英文联系作者: Nardini, C (reprint author), Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Grp Clin Genom Networks, Key Lab Computat Biol, Shanghai 200031, Peoples R China.
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发表年度: 2016
卷: 6
期:
页码: 39043
摘要: Degeneration is a hallmark of autoimmune diseases, whose incidence grows worldwide. Current therapies attempt to control the immune response to limit degeneration, commonly promoting immunodepression. Differently, mechanical stimulation is known to trigger healing (regeneration) and it has recently been proposed locally for its therapeutic potential on severely injured areas. As the early stages of healing consist of altered intra-and inter-cellular fluxes of soluble molecules, we explored the potential of this early signal to spread, over time, beyond the stimulation district and become systemic, to impact on distributed or otherwise unreachable injured areas. We report in a model of arthritis in rats how stimulations delivered in the subcutaneous dorsal tissue result, over time, in the control and healing of the degeneration of the paws' joints, concomitantly with the systemic activation of wound healing phenomena in blood and in correlation with a more eubiotic microbiome in the gut intestinal district.
英文摘要: Degeneration is a hallmark of autoimmune diseases, whose incidence grows worldwide. Current therapies attempt to control the immune response to limit degeneration, commonly promoting immunodepression. Differently, mechanical stimulation is known to trigger healing (regeneration) and it has recently been proposed locally for its therapeutic potential on severely injured areas. As the early stages of healing consist of altered intra-and inter-cellular fluxes of soluble molecules, we explored the potential of this early signal to spread, over time, beyond the stimulation district and become systemic, to impact on distributed or otherwise unreachable injured areas. We report in a model of arthritis in rats how stimulations delivered in the subcutaneous dorsal tissue result, over time, in the control and healing of the degeneration of the paws' joints, concomitantly with the systemic activation of wound healing phenomena in blood and in correlation with a more eubiotic microbiome in the gut intestinal district.
刊物名称: SCIENTIFIC REPORTS
英文刊物名称: SCIENTIFIC REPORTS
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学科: Multidisciplinary Sciences
英文学科: Multidisciplinary Sciences
影响因子: 4.259
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论文类别: Article
英文论文类别: Article
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