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论文题目: Refined phylogenetic structure of an abundant East Asian Y-chromosomal haplogroup O*-M134
英文论文题目: Refined phylogenetic structure of an abundant East Asian Y-chromosomal haplogroup O*-M134
第一作者: Ning, C; Yan, S; Hu, K; Cui, YQ; Jin, L
英文第一作者: Ning, C; Yan, S; Hu, K; Cui, YQ; Jin, L
联系作者: Cui, YQ (reprint author), Jilin Univ, Sch Life Sci, 2699 Qianjing St, Changchun 130012, Peoples R China.
英文联系作者: Cui, YQ (reprint author), Jilin Univ, Sch Life Sci, 2699 Qianjing St, Changchun 130012, Peoples R China.
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发表年度: 2016
卷: 24
期: 2
页码: 307-309
摘要: The human Y-chromosome haplogroup O-M134 is one of the most abundant paternal lineages in East Asian populations, comprising similar to 13% of Han Chinese males, and also common in Kazakh, Korean, Japanese, Thai and so on. Despite its considerable prevalence, its current substructure is poorly resolved with only one downstream marker (M117) previously investigated. Here we address this deficiency by investigating some single-nucleotide polymorphisms (SNPs) previously reported being potentially associated with O-M134 based on high-throughput DNA-sequencing data. Using a panel of 1301 Chinese males we first identified 154 haplogroup O-M134 subjects. We then investigated the phylogenetic structure within this haplogroup using 10 SNPs (F444, F629, F3451, F46, F48, F209, F2887, F3386, F1739 and F152). Two major branches were identified, O-M117 and O-F444 and the latter was further divided into two main subclades, O-F629 and O-F3451, accounting for 10.84 and 0.92% of the Han Chinese, respectively. This update of O-M134 diversification permits better resolution of male lineages in population studies of East Asia.
英文摘要: The human Y-chromosome haplogroup O-M134 is one of the most abundant paternal lineages in East Asian populations, comprising similar to 13% of Han Chinese males, and also common in Kazakh, Korean, Japanese, Thai and so on. Despite its considerable prevalence, its current substructure is poorly resolved with only one downstream marker (M117) previously investigated. Here we address this deficiency by investigating some single-nucleotide polymorphisms (SNPs) previously reported being potentially associated with O-M134 based on high-throughput DNA-sequencing data. Using a panel of 1301 Chinese males we first identified 154 haplogroup O-M134 subjects. We then investigated the phylogenetic structure within this haplogroup using 10 SNPs (F444, F629, F3451, F46, F48, F209, F2887, F3386, F1739 and F152). Two major branches were identified, O-M117 and O-F444 and the latter was further divided into two main subclades, O-F629 and O-F3451, accounting for 10.84 and 0.92% of the Han Chinese, respectively. This update of O-M134 diversification permits better resolution of male lineages in population studies of East Asia.
刊物名称: EUROPEAN JOURNAL OF HUMAN GENETICS
英文刊物名称: EUROPEAN JOURNAL OF HUMAN GENETICS
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学科: Biochemistry & Molecular Biology; Genetics & Heredity
英文学科: Biochemistry & Molecular Biology; Genetics & Heredity
影响因子: 4.287
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论文类别: Article
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