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论文题目: A synthetic bridging patch of modified co-electrospun dual nano-scaffolds for massive rotator cuff tear
英文论文题目: A synthetic bridging patch of modified co-electrospun dual nano-scaffolds for massive rotator cuff tear
第一作者: Sun, YY; Han, F; Zhang, P; Zhi, YL; Yang, JJ; Yao, XH; Wang, H; Lin, C; Wen, XJ; Chen, JW; Zhao, P
英文第一作者: Sun, YY; Han, F; Zhang, P; Zhi, YL; Yang, JJ; Yao, XH; Wang, H; Lin, C; Wen, XJ; Chen, JW; Zhao, P
联系作者: Chen, JW (reprint author), Fudan Univ, Huashan Hosp, Dept Sports Med, 12 Middle Wulumuqi Rd, Shanghai 200040, Peoples R China.
英文联系作者: Chen, JW (reprint author), Fudan Univ, Huashan Hosp, Dept Sports Med, 12 Middle Wulumuqi Rd, Shanghai 200040, Peoples R China.
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发表年度: 2016
卷: 4
期: 45
页码: 7259-7269
摘要: Massive rotator cuff tears (MRCTs) are difficult to repair because of the retraction and poor mobility of torn tendons. In the current study, co-electrospun dual nano-scaffolds of poly(lactic-co-glycolic acid)/collagen I-polycaprolactone/nanohydroxyapatite (PLGA/Col-PCL/nHA) were fabricated and used to bridge MRCTs of infraspinatus tendons in a rabbit model. PLGA-PCL served as a control. The PLGA or the PLGA/Col sides of the dual scaffolds connected the tendon stumps. The PCL or PCL/nHA side was inserted into the bone tunnel at the insertion of the infraspinatus tendon. Fibroblasts showed higher viability and collagen secretion when seeded on a PLGA/Col scaffold compared to a PLGA scaffold. Osteoblasts seeded on a PCL/nHA scaffold grew better with higher mineralization than on a PCL scaffold. Histologically, collagen regenerated along PLGA scaffolds, but showed poor ingrowth to scaffolds compared with the PLGA/Col group. Newly formed bone was observed on the PCL scaffold, but was less than that on the PCL/nHA scaffold. At 6 weeks post repair, the regenerated tendon in both groups had similar maximum load to failure and ultimate stress but significantly lower stiffness in the PLGA-PCL group and a higher cross-sectional area in the PLGA/Col-PCL/nHA group compared with normal values. At 12 weeks, the maximum failure load, ultimate stress and cross-sectional areas of the regenerated tendon in the PLGA/Col-PCL/nHA group were significantly higher than in the PLGA-PCL and normal groups. The biomechanical properties of the PLGA-PCL group were similar to normal except for a larger cross-sectional area. Our data showed that the co-electrospun dual nano-scaffolds are promising in bridging MRCTs. Doping with Col and nHA further strengthens tissue regeneration.
英文摘要: Massive rotator cuff tears (MRCTs) are difficult to repair because of the retraction and poor mobility of torn tendons. In the current study, co-electrospun dual nano-scaffolds of poly(lactic-co-glycolic acid)/collagen I-polycaprolactone/nanohydroxyapatite (PLGA/Col-PCL/nHA) were fabricated and used to bridge MRCTs of infraspinatus tendons in a rabbit model. PLGA-PCL served as a control. The PLGA or the PLGA/Col sides of the dual scaffolds connected the tendon stumps. The PCL or PCL/nHA side was inserted into the bone tunnel at the insertion of the infraspinatus tendon. Fibroblasts showed higher viability and collagen secretion when seeded on a PLGA/Col scaffold compared to a PLGA scaffold. Osteoblasts seeded on a PCL/nHA scaffold grew better with higher mineralization than on a PCL scaffold. Histologically, collagen regenerated along PLGA scaffolds, but showed poor ingrowth to scaffolds compared with the PLGA/Col group. Newly formed bone was observed on the PCL scaffold, but was less than that on the PCL/nHA scaffold. At 6 weeks post repair, the regenerated tendon in both groups had similar maximum load to failure and ultimate stress but significantly lower stiffness in the PLGA-PCL group and a higher cross-sectional area in the PLGA/Col-PCL/nHA group compared with normal values. At 12 weeks, the maximum failure load, ultimate stress and cross-sectional areas of the regenerated tendon in the PLGA/Col-PCL/nHA group were significantly higher than in the PLGA-PCL and normal groups. The biomechanical properties of the PLGA-PCL group were similar to normal except for a larger cross-sectional area. Our data showed that the co-electrospun dual nano-scaffolds are promising in bridging MRCTs. Doping with Col and nHA further strengthens tissue regeneration.
刊物名称: JOURNAL OF MATERIALS CHEMISTRY B
英文刊物名称: JOURNAL OF MATERIALS CHEMISTRY B
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学科: Materials Science, Biomaterials
英文学科: Materials Science, Biomaterials
影响因子: 4.543
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论文类别: Article
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