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论文题目: Sperm tsRNAs and acquired metabolic disorders
英文论文题目: Sperm tsRNAs and acquired metabolic disorders
第一作者: Yan, MH; Zhai, QW
英文第一作者: Yan, MH; Zhai, QW
联系作者: Zhai, QW (reprint author), Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, CAS Key Lab Nutr & Metab, Inst Nutr Sci,Shanghai Inst Biol Sci, Shanghai, Peoples R China.
英文联系作者: Zhai, QW (reprint author), Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, CAS Key Lab Nutr & Metab, Inst Nutr Sci,Shanghai Inst Biol Sci, Shanghai, Peoples R China.
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发表年度: 2016
卷: 230
期: 3
页码: F13-F18
摘要: Many findings support the hypothesis that metabolic changes associated with environmental factors can be transmitted from father to offspring. The molecular mechanisms underlying the intergenerational transmission of metabolic changes remain to be fully explored. These acquired metabolic disorders in offspring may be partially explained by some potential epigenetic information carriers such as DNA methylation, histone modification and small non-coding RNAs. Recent evidence shows that sperm tRNA-derived small RNAs (tsRNAs) as a type of paternal epigenetic information carrier may mediate intergenerational inheritance. In this review, we provide current knowledge of a father's influence on metabolic disorders in subsequent generations and discuss the roles of sperm tsRNAs and their modifications in paternal epigenetic information transmission.
英文摘要: Many findings support the hypothesis that metabolic changes associated with environmental factors can be transmitted from father to offspring. The molecular mechanisms underlying the intergenerational transmission of metabolic changes remain to be fully explored. These acquired metabolic disorders in offspring may be partially explained by some potential epigenetic information carriers such as DNA methylation, histone modification and small non-coding RNAs. Recent evidence shows that sperm tRNA-derived small RNAs (tsRNAs) as a type of paternal epigenetic information carrier may mediate intergenerational inheritance. In this review, we provide current knowledge of a father's influence on metabolic disorders in subsequent generations and discuss the roles of sperm tsRNAs and their modifications in paternal epigenetic information transmission.
刊物名称: JOURNAL OF ENDOCRINOLOGY
英文刊物名称: JOURNAL OF ENDOCRINOLOGY
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学科: Endocrinology & Metabolism
英文学科: Endocrinology & Metabolism
影响因子: 4.706
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论文类别: Article
英文论文类别: Article
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