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论文题目: The effects of graded levels of calorie restriction: VI. Impact of short-term graded calorie restriction on transcriptomic responses of the hypothalamic hunger and circadian signaling pathways
英文论文题目: The effects of graded levels of calorie restriction: VI. Impact of short-term graded calorie restriction on transcriptomic responses of the hypothalamic hunger and circadian signaling pathways
第一作者: Derous, D; Mitchell, SE; Green, CL; Chen, LN; Han, JDJ; Wang, YC; Promislow, DEL; Lusseau, D; Speakman, JR; Douglas, A
英文第一作者: Derous, D; Mitchell, SE; Green, CL; Chen, LN; Han, JDJ; Wang, YC; Promislow, DEL; Lusseau, D; Speakman, JR; Douglas, A
联系作者: Speakman, JR; Douglas, A (reprint author), Univ Aberdeen, Inst Biol & Environm Sci, Aberdeen AB24 2TZ, Scotland.
英文联系作者: Speakman, JR; Douglas, A (reprint author), Univ Aberdeen, Inst Biol & Environm Sci, Aberdeen AB24 2TZ, Scotland.
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发表年度: 2016
卷: 8
期: 4
页码: 642-663
摘要: Food intake and circadian rhythms are regulated by hypothalamic neuropeptides and circulating hormones, which could mediate the anti-ageing effect of calorie restriction (CR). We tested whether these two signaling pathways mediate CR by quantifying hypothalamic transcripts of male C57BL/6 mice exposed to graded levels of CR (10 % to 40 %) for 3 months. We found that the graded CR manipulation resulted in upregulation of core circadian rhythm genes, which correlated negatively with circulating levels of leptin, insulin-like growth factor 1 (IGF-1), insulin, and tumor necrosis factor alpha (TNF-alpha). In addition, key components in the hunger signaling pathway were expressed in a manner reflecting elevated hunger at greater levels of restriction, and which also correlated negatively with circulating levels of insulin, TNF-alpha, leptin and IGF-1. Lastly, phenotypes, such as food anticipatory activity and body temperature, were associated with expression levels of both hunger genes and core clock genes. Our results suggest modulation of the hunger and circadian signaling pathways in response to altered levels of circulating hormones, that are themselves downstream of morphological changes resulting from CR treatment, may be important elements in the response to CR, driving some of the key phenotypic outcomes.
英文摘要: Food intake and circadian rhythms are regulated by hypothalamic neuropeptides and circulating hormones, which could mediate the anti-ageing effect of calorie restriction (CR). We tested whether these two signaling pathways mediate CR by quantifying hypothalamic transcripts of male C57BL/6 mice exposed to graded levels of CR (10 % to 40 %) for 3 months. We found that the graded CR manipulation resulted in upregulation of core circadian rhythm genes, which correlated negatively with circulating levels of leptin, insulin-like growth factor 1 (IGF-1), insulin, and tumor necrosis factor alpha (TNF-alpha). In addition, key components in the hunger signaling pathway were expressed in a manner reflecting elevated hunger at greater levels of restriction, and which also correlated negatively with circulating levels of insulin, TNF-alpha, leptin and IGF-1. Lastly, phenotypes, such as food anticipatory activity and body temperature, were associated with expression levels of both hunger genes and core clock genes. Our results suggest modulation of the hunger and circadian signaling pathways in response to altered levels of circulating hormones, that are themselves downstream of morphological changes resulting from CR treatment, may be important elements in the response to CR, driving some of the key phenotypic outcomes.
刊物名称: AGING-US
英文刊物名称: AGING-US
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学科: Cell Biology
英文学科: Cell Biology
影响因子: 4.867
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论文类别: Article
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