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论文题目: The effects of graded levels of calorie restriction: VII. Topological rearrangement of hypothalamic aging networks
英文论文题目: The effects of graded levels of calorie restriction: VII. Topological rearrangement of hypothalamic aging networks
第一作者: Derous, D; Mitchell, SE; Green, CL; Wang, YC; Han, JDJ; Chen, LN; Promislow, DEL; Lusseau, D; Speakman, JR; Douglas, A
英文第一作者: Derous, D; Mitchell, SE; Green, CL; Wang, YC; Han, JDJ; Chen, LN; Promislow, DEL; Lusseau, D; Speakman, JR; Douglas, A
联系作者: Lusseau, D; Speakman, JR; Douglas, A (reprint author), Univ Aberdeen, Inst Biol & Environm Sci, Aberdeen AB24 2TZ, Scotland.
英文联系作者: Lusseau, D; Speakman, JR; Douglas, A (reprint author), Univ Aberdeen, Inst Biol & Environm Sci, Aberdeen AB24 2TZ, Scotland.
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发表年度: 2016
卷: 8
期: 5
页码: 917-932
摘要: Connectivity in a gene-gene network declines with age, typically within gene clusters. We explored the effect of short-term (3 months) graded calorie restriction (CR) (up to 40 %) on network structure of aging-associated genes in the murine hypothalamus by using conditional mutual information. The networks showed a topological rearrangement when exposed to graded CR with a higher relative within cluster connectivity at 40CR. We observed changes in gene centrality concordant with changes in CR level, with Ppargc1a, and Ppt1 having increased centrality and Etfdh, Traf3 and Abcc1 decreased centrality as CR increased. This change in gene centrality in a graded manner with CR, occurred in the absence of parallel changes in gene expression levels. This study emphasizes the importance of augmenting traditional differential gene expression analyses to better understand structural changes in the transcriptome. Overall our results suggested that CR induced changes in centrality of biological relevant genes that play an important role in preventing the age-associated loss of network integrity irrespective of their gene expression levels.
英文摘要: Connectivity in a gene-gene network declines with age, typically within gene clusters. We explored the effect of short-term (3 months) graded calorie restriction (CR) (up to 40 %) on network structure of aging-associated genes in the murine hypothalamus by using conditional mutual information. The networks showed a topological rearrangement when exposed to graded CR with a higher relative within cluster connectivity at 40CR. We observed changes in gene centrality concordant with changes in CR level, with Ppargc1a, and Ppt1 having increased centrality and Etfdh, Traf3 and Abcc1 decreased centrality as CR increased. This change in gene centrality in a graded manner with CR, occurred in the absence of parallel changes in gene expression levels. This study emphasizes the importance of augmenting traditional differential gene expression analyses to better understand structural changes in the transcriptome. Overall our results suggested that CR induced changes in centrality of biological relevant genes that play an important role in preventing the age-associated loss of network integrity irrespective of their gene expression levels.
刊物名称: AGING-US
英文刊物名称: AGING-US
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学科: Cell Biology
英文学科: Cell Biology
影响因子: 4.867
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论文类别: Article
英文论文类别: Article
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