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论文题目: FAM122A, a new endogenous inhibitor of protein phosphatase 2A
英文论文题目: FAM122A, a new endogenous inhibitor of protein phosphatase 2A
第一作者: Fan, L; Liu, MH; Guo, M; Hu, CX; Yan, ZW; Chen, J; Chen, GQ; Huang, Y
英文第一作者: Fan, L; Liu, MH; Guo, M; Hu, CX; Yan, ZW; Chen, J; Chen, GQ; Huang, Y
联系作者: Huang, Y (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200025, Peoples R China.
英文联系作者: Huang, Y (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200025, Peoples R China.
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发表年度: 2016
卷: 7
期: 39
页码: 63887-63900
摘要: The regulation of the ubiquitously expressed protein phosphatase 2A (PP2A) is essential for various cellular functions such as cell proliferation, transformation, and fate determination. In this study, we demonstrate that the highly conserved protein in mammals, designated FAM122A, directly interacts with PP2A-Aa and B55a rather than B56a subunits, and inhibits the phosphatase activity of PP2A-Aa/B55a/Ca complex. Further, FAM122A potentiates the degradation of catalytic subunit PP2A-Ca with the increased poly-ubiquitination. In agreement, FAM122A silencing inhibits while its overexpression enhances cell growth and colony- forming ability. Collectively, we identify FAM122A as a new endogenous PP2A inhibitor and its physiological and pathophysiological significances warrant to be further investigated.
英文摘要: The regulation of the ubiquitously expressed protein phosphatase 2A (PP2A) is essential for various cellular functions such as cell proliferation, transformation, and fate determination. In this study, we demonstrate that the highly conserved protein in mammals, designated FAM122A, directly interacts with PP2A-Aa and B55a rather than B56a subunits, and inhibits the phosphatase activity of PP2A-Aa/B55a/Ca complex. Further, FAM122A potentiates the degradation of catalytic subunit PP2A-Ca with the increased poly-ubiquitination. In agreement, FAM122A silencing inhibits while its overexpression enhances cell growth and colony- forming ability. Collectively, we identify FAM122A as a new endogenous PP2A inhibitor and its physiological and pathophysiological significances warrant to be further investigated.
刊物名称: ONCOTARGET
英文刊物名称: ONCOTARGET
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学科: Oncology; Cell Biology
英文学科: Oncology; Cell Biology
影响因子: 5.168
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论文类别: Article
英文论文类别: Article
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