论文库首页  论文库
 
论文编号:
论文题目: The roles and functional mechanisms of interleukin-17 family cytokines in mucosal immunity
英文论文题目: The roles and functional mechanisms of interleukin-17 family cytokines in mucosal immunity
第一作者: Song, XY; He, X; Li, XX; Qian, YC
英文第一作者: Song, XY; He, X; Li, XX; Qian, YC
联系作者: Qian, YC (reprint author), Shanghai Jiao Tong Univ, Sch Med, Chinese Acad Sci, Shanghai Inst Biol Sci,Inst Hlth Sci, Shanghai 200025, Peoples R China.
英文联系作者: Qian, YC (reprint author), Shanghai Jiao Tong Univ, Sch Med, Chinese Acad Sci, Shanghai Inst Biol Sci,Inst Hlth Sci, Shanghai 200025, Peoples R China.
外单位作者单位:
英文外单位作者单位:
发表年度: 2016
卷: 13
期: 4
页码: 418-431
摘要: The mucosal immune system serves as our front-line defense against pathogens. It also tightly maintains immune tolerance to self-symbiotic bacteria, which are usually called commensals. Sensing both types of microorganisms is modulated by signalling primarily through various pattern-recognition receptors (PRRs) on barrier epithelial cells or immune cells. After sensing, proinflammatory molecules such as cytokines are released by these cells to mediate either defensive or tolerant responses. The interleukin-17 (IL-17) family members belong to a newly characterized cytokine subset that is critical for the maintenance of mucosal homeostasis. In this review, we will summarize recent progress on the diverse functions and signals of this family of cytokines at different mucosal edges.
英文摘要: The mucosal immune system serves as our front-line defense against pathogens. It also tightly maintains immune tolerance to self-symbiotic bacteria, which are usually called commensals. Sensing both types of microorganisms is modulated by signalling primarily through various pattern-recognition receptors (PRRs) on barrier epithelial cells or immune cells. After sensing, proinflammatory molecules such as cytokines are released by these cells to mediate either defensive or tolerant responses. The interleukin-17 (IL-17) family members belong to a newly characterized cytokine subset that is critical for the maintenance of mucosal homeostasis. In this review, we will summarize recent progress on the diverse functions and signals of this family of cytokines at different mucosal edges.
刊物名称: CELLULAR & MOLECULAR IMMUNOLOGY
英文刊物名称: CELLULAR & MOLECULAR IMMUNOLOGY
论文全文:
英文论文全文:
全文链接:
其它备注:
英文其它备注:
学科: Immunology
英文学科: Immunology
影响因子: 5.897
第一作者所在部门:
英文第一作者所在部门:
论文出处:
英文论文出处:
论文类别: Article
英文论文类别: Article
参与作者:
英文参与作者:
 
2014 中国科学院上海生命科学研究院 版权所有