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论文题目: RelB/NF-kappa B links cell cycle transition and apoptosis to endometrioid adenocarcinoma tumorigenesis
英文论文题目: RelB/NF-kappa B links cell cycle transition and apoptosis to endometrioid adenocarcinoma tumorigenesis
第一作者: Ge, QL; Liu, SH; Ai, ZH; Tao, MF; Ma, L; Wen, SY; Dai, M; Liu, F; Liu, HS; Jiang, RZ; Xue, ZW; Jiang, YH; Sun, XH; Hu, YM; Zhao, YX; Chen, X; Tao, Y; Zhu, XL; Ding, WJ; Yang, BQ; Liu, DD; Zhang, XR; Teng, YC
英文第一作者: Ge, QL; Liu, SH; Ai, ZH; Tao, MF; Ma, L; Wen, SY; Dai, M; Liu, F; Liu, HS; Jiang, RZ; Xue, ZW; Jiang, YH; Sun, XH; Hu, YM; Zhao, YX; Chen, X; Tao, Y; Zhu, XL; Ding, WJ; Yang, BQ; Liu, DD; Zhang, XR; Teng, YC
联系作者: Zhang, XR (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai 200031, Peoples R China.
英文联系作者: Zhang, XR (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai 200031, Peoples R China.
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发表年度: 2016
卷: 7
期:
页码: e2402
摘要: Dysfunction of nuclear factor-kappa B (NF-kappa B) signaling has been causally associated with numerous human malignancies. Although the NF-kappa B family of genes has been implicated in endometrial carcinogenesis, information regarding the involvement of central regulators of NF-kappa B signaling in human endometrial cancer (EC) is limited. Here, we investigated the specific roles of canonical and noncanonical NF-kappa B signaling in endometrial tumorigenesis. We found that NF-kappa B RelB protein, but not RelA, displayed high expression in EC samples and cell lines, with predominant elevation in endometrioid adenocarcinoma (EEC). Moreover, tumor cell-intrinsic RelB was responsible for the abundant levels of c-Myc, cyclin D1, Bcl-2 and Bcl-xL, which are key regulators of cell cycle transition, apoptosis and proliferation in EEC. In contrast, p27 expression was enhanced by RelB depletion. Thus, increased RelB in human EC is associated with enhanced EEC cell growth, leading to endometrial cell tumorigenicity. Our results reveal that regulatory RelB in noncanonical NF-kappa B signaling may serve as a therapeutic target to block EC initiation.
英文摘要: Dysfunction of nuclear factor-kappa B (NF-kappa B) signaling has been causally associated with numerous human malignancies. Although the NF-kappa B family of genes has been implicated in endometrial carcinogenesis, information regarding the involvement of central regulators of NF-kappa B signaling in human endometrial cancer (EC) is limited. Here, we investigated the specific roles of canonical and noncanonical NF-kappa B signaling in endometrial tumorigenesis. We found that NF-kappa B RelB protein, but not RelA, displayed high expression in EC samples and cell lines, with predominant elevation in endometrioid adenocarcinoma (EEC). Moreover, tumor cell-intrinsic RelB was responsible for the abundant levels of c-Myc, cyclin D1, Bcl-2 and Bcl-xL, which are key regulators of cell cycle transition, apoptosis and proliferation in EEC. In contrast, p27 expression was enhanced by RelB depletion. Thus, increased RelB in human EC is associated with enhanced EEC cell growth, leading to endometrial cell tumorigenicity. Our results reveal that regulatory RelB in noncanonical NF-kappa B signaling may serve as a therapeutic target to block EC initiation.
刊物名称: CELL DEATH & DISEASE
英文刊物名称: CELL DEATH & DISEASE
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学科: Cell Biology
英文学科: Cell Biology
影响因子: 5.965
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论文类别: Article
英文论文类别: Article
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