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论文题目: Amygdala EphB2 Signaling Regulates Glutamatergic Neuron Maturation and Innate Fear
英文论文题目: Amygdala EphB2 Signaling Regulates Glutamatergic Neuron Maturation and Innate Fear
第一作者: Zhu, XN; Liu, XD; Zhuang, HY; Henkemeyer, M; Yang, JY; Xu, NJ
英文第一作者: Zhu, XN; Liu, XD; Zhuang, HY; Henkemeyer, M; Yang, JY; Xu, NJ
联系作者: Xu, NJ (reprint author), Shanghai Jiao Tong Univ, Sch Med, 280 South Chong Qing Rd, Shanghai 200025, Peoples R China.
英文联系作者: Xu, NJ (reprint author), Shanghai Jiao Tong Univ, Sch Med, 280 South Chong Qing Rd, Shanghai 200025, Peoples R China.
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发表年度: 2016
卷: 36
期: 39
页码: 10151-10162
摘要: The amygdala serves as emotional center to mediate innate fear behaviors that are reflected through neuronal responses to environmental aversive cues. However, the molecular mechanism underlying the initial neuron responses is poorly understood. In this study, we monitored the innate defensive responses to aversive stimuli of either elevated plus maze or predator odor in juvenile mice and found that glutamatergic neurons were activated in amygdala. Loss of EphB2, a receptor tyrosine kinase expressed in amygdala neurons, suppressed the reactions and led to defects in spine morphogenesis and fear behaviors. We further found a coupling of spinogenesis with these threat cues induced neuron activation in developing amygdala that was controlled by EphB2. A constitutively active form of EphB2 was sufficient to rescue the behavioral and morphological defects caused by ablation of ephrin-B3, a brain-enriched ligand to EphB2. These data suggest that kinase-dependent EphB2 intracellular signaling plays a major role for innate fear responses during the critical developing period, in which spinogenesis in amygdala glutamatergic neurons was involved.
英文摘要: The amygdala serves as emotional center to mediate innate fear behaviors that are reflected through neuronal responses to environmental aversive cues. However, the molecular mechanism underlying the initial neuron responses is poorly understood. In this study, we monitored the innate defensive responses to aversive stimuli of either elevated plus maze or predator odor in juvenile mice and found that glutamatergic neurons were activated in amygdala. Loss of EphB2, a receptor tyrosine kinase expressed in amygdala neurons, suppressed the reactions and led to defects in spine morphogenesis and fear behaviors. We further found a coupling of spinogenesis with these threat cues induced neuron activation in developing amygdala that was controlled by EphB2. A constitutively active form of EphB2 was sufficient to rescue the behavioral and morphological defects caused by ablation of ephrin-B3, a brain-enriched ligand to EphB2. These data suggest that kinase-dependent EphB2 intracellular signaling plays a major role for innate fear responses during the critical developing period, in which spinogenesis in amygdala glutamatergic neurons was involved.
刊物名称: JOURNAL OF NEUROSCIENCE
英文刊物名称: JOURNAL OF NEUROSCIENCE
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学科: Neurosciences
英文学科: Neurosciences
影响因子: 5.988
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论文类别: Article
英文论文类别: Article
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