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论文题目: Global profiling of cellular targets of gambogic acid by quantitative chemical proteomics
英文论文题目: Global profiling of cellular targets of gambogic acid by quantitative chemical proteomics
第一作者: Zhou, YQ; Li, WC; Zhang, XX; Zhang, HB; Xiao, YL
英文第一作者: Zhou, YQ; Li, WC; Zhang, XX; Zhang, HB; Xiao, YL
联系作者: Xiao, YL (reprint author), Chinese Acad Sci, CAS Ctr Excellence Mol Plant Sci, CAS Key Lab Synthet Biol, Inst Plant Physiol & Ecol,Shanghai Inst Biol Sci, Shanghai 200032, Peoples R China.
英文联系作者: Xiao, YL (reprint author), Chinese Acad Sci, CAS Ctr Excellence Mol Plant Sci, CAS Key Lab Synthet Biol, Inst Plant Physiol & Ecol,Shanghai Inst Biol Sci, Shanghai 200032, Peoples R China.
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发表年度: 2016
卷: 52
期: 97
页码: 14035-14038
摘要: Gambogic acid has shown significant potential as an anti-cancer and anti-inflammatory compound; however, the molecular mechanism underlying the actions of gambogic acid, particularly its cellular target profiles, has not been investigated. In this study, we report the proteome-wide profiling of potential cellular targets of gambogic acid using quantitative mass spectrometry-based chemical proteomics. The target profiles of gambogic acid in living HeLa and K562 cells were identified, which strengthened our understanding of the mode of actions of the phytochemical.
英文摘要: Gambogic acid has shown significant potential as an anti-cancer and anti-inflammatory compound; however, the molecular mechanism underlying the actions of gambogic acid, particularly its cellular target profiles, has not been investigated. In this study, we report the proteome-wide profiling of potential cellular targets of gambogic acid using quantitative mass spectrometry-based chemical proteomics. The target profiles of gambogic acid in living HeLa and K562 cells were identified, which strengthened our understanding of the mode of actions of the phytochemical.
刊物名称: CHEMICAL COMMUNICATIONS
英文刊物名称: CHEMICAL COMMUNICATIONS
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学科: Chemistry, Multidisciplinary
英文学科: Chemistry, Multidisciplinary
影响因子: 6.319
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论文类别: Article
英文论文类别: Article
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