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论文题目: Formylpeptide receptor 1 mediates the tumorigenicity of human hepatocellular carcinoma cells
英文论文题目: Formylpeptide receptor 1 mediates the tumorigenicity of human hepatocellular carcinoma cells
第一作者: Zhang, L; Wang, HY; Yang, TS; Su, ZF; Fang, D; Wang, YF; Fang, JZ; Hou, XW; Le, YY; Chen, KQ; Wang, JM; Su, SB; Lin, Q; Zhou, Q
英文第一作者: Zhang, L; Wang, HY; Yang, TS; Su, ZF; Fang, D; Wang, YF; Fang, JZ; Hou, XW; Le, YY; Chen, KQ; Wang, JM; Su, SB; Lin, Q; Zhou, Q
联系作者: Zhou, Q (reprint author), Sun Yat Sen Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Guangzhou 510275, Guangdong, Peoples R China.
英文联系作者: Zhou, Q (reprint author), Sun Yat Sen Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Guangzhou 510275, Guangdong, Peoples R China.
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发表年度: 2016
卷: 5
期: 2
页码: e1078055
摘要: G protein-coupled chemoattractant receptors (GPCRs) have been implicated in cancer progression. Formylpeptide receptor 1 (FPR1) was originally identified as a GPCR mediating anti-microbial host defense. However, the role of FPR1 in tumorigenesis remains poorly understood. The current study aims to investigate the potential of FPR1 to regulate human hepatoma growth and invasion. We found the FPR1 gene and protein expression in human intratumoral and peritumoral tissues of hepatocellular carcinoma (HCC) specimens and in human hepatoma cell lines. FPR1 activation mediated the migration, calcium mobilization and ERK-dependent IL-8 production by hepatic cancer cells. FPR1 knockdown substantially reduced the tumorigenicity of hepatoma cells in nude mice. Necrotic hepatic tumor cells released factor(s) that activated FPR1 in live tumor cells. Our results indicate a critical role of FPR1 in the progression of malignant human hepatic cancer. FPR1 thus may represent a molecular target for the development of novel anti-hepatoma therapeutics.
英文摘要: G protein-coupled chemoattractant receptors (GPCRs) have been implicated in cancer progression. Formylpeptide receptor 1 (FPR1) was originally identified as a GPCR mediating anti-microbial host defense. However, the role of FPR1 in tumorigenesis remains poorly understood. The current study aims to investigate the potential of FPR1 to regulate human hepatoma growth and invasion. We found the FPR1 gene and protein expression in human intratumoral and peritumoral tissues of hepatocellular carcinoma (HCC) specimens and in human hepatoma cell lines. FPR1 activation mediated the migration, calcium mobilization and ERK-dependent IL-8 production by hepatic cancer cells. FPR1 knockdown substantially reduced the tumorigenicity of hepatoma cells in nude mice. Necrotic hepatic tumor cells released factor(s) that activated FPR1 in live tumor cells. Our results indicate a critical role of FPR1 in the progression of malignant human hepatic cancer. FPR1 thus may represent a molecular target for the development of novel anti-hepatoma therapeutics.
刊物名称: ONCOIMMUNOLOGY
英文刊物名称: ONCOIMMUNOLOGY
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学科: Oncology; Immunology
英文学科: Oncology; Immunology
影响因子: 7.719
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论文类别: Article
英文论文类别: Article
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