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论文题目: The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice
英文论文题目: The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice
第一作者: Ju, XC; Hou, QQ; Sheng, AL; Wu, KY; Zhou, Y; Jin, Y; Wen, TQ; Yang, ZG; Wang, XQ; Luo, ZG
英文第一作者: Ju, XC; Hou, QQ; Sheng, AL; Wu, KY; Zhou, Y; Jin, Y; Wen, TQ; Yang, ZG; Wang, XQ; Luo, ZG
联系作者: Luo, ZG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China.
英文联系作者: Luo, ZG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China.
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发表年度: 2016
卷: 5
期:
页码: e18197
摘要: Cortical expansion and folding are often linked to the evolution of higher intelligence, but molecular and cellular mechanisms underlying cortical folding remain poorly understood. The hominoid-specific gene TBC1D3 undergoes segmental duplications during hominoid evolution, but its role in brain development has not been explored. Here, we found that expression of TBC1D3 in ventricular cortical progenitors of mice via in utero electroporation caused delamination of ventricular radial glia cells (vRGs) and promoted generation of self-renewing basal progenitors with typical morphology of outer radial glia (oRG), which are most abundant in primates. Furthermore, down-regulation of TBC1D3 in cultured human brain slices decreased generation of oRGs. Interestingly, localized oRG proliferation resulting from either in utero electroporation or transgenic expression of TBC1D3, was often found to underlie cortical regions exhibiting folding. Thus, we have identified a hominoid gene that is required for oRG generation in regulating the cortical expansion and folding.
英文摘要: Cortical expansion and folding are often linked to the evolution of higher intelligence, but molecular and cellular mechanisms underlying cortical folding remain poorly understood. The hominoid-specific gene TBC1D3 undergoes segmental duplications during hominoid evolution, but its role in brain development has not been explored. Here, we found that expression of TBC1D3 in ventricular cortical progenitors of mice via in utero electroporation caused delamination of ventricular radial glia cells (vRGs) and promoted generation of self-renewing basal progenitors with typical morphology of outer radial glia (oRG), which are most abundant in primates. Furthermore, down-regulation of TBC1D3 in cultured human brain slices decreased generation of oRGs. Interestingly, localized oRG proliferation resulting from either in utero electroporation or transgenic expression of TBC1D3, was often found to underlie cortical regions exhibiting folding. Thus, we have identified a hominoid gene that is required for oRG generation in regulating the cortical expansion and folding.
刊物名称: ELIFE
英文刊物名称: ELIFE
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学科: Biology
英文学科: Biology
影响因子: 7.725
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论文类别: Article
英文论文类别: Article
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