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论文题目: Differences and similarities between human and chimpanzee neural progenitors during cerebral cortex development
英文论文题目: Differences and similarities between human and chimpanzee neural progenitors during cerebral cortex development
第一作者: Mora-Bermudez, F; Badsha, F; Kanton, S; Camp, JG; Vernot, B; Kohler, K; Voigt, B; Okita, K; Maricic, T; He, ZS; Lachmann, R; Paabo, S; Treutlein, B; Huttner, WB
英文第一作者: Mora-Bermudez, F; Badsha, F; Kanton, S; Camp, JG; Vernot, B; Kohler, K; Voigt, B; Okita, K; Maricic, T; He, ZS; Lachmann, R; Paabo, S; Treutlein, B; Huttner, WB
联系作者: Treutlein, B; Huttner, WB (reprint author), Max Planck Inst Mol Cell Biol & Genet, Dresden, Germany.
英文联系作者: Treutlein, B; Huttner, WB (reprint author), Max Planck Inst Mol Cell Biol & Genet, Dresden, Germany.
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发表年度: 2016
卷: 5
期:
页码: e18683
摘要: Human neocortex expansion likely contributed to the remarkable cognitive abilities of humans. This expansion is thought to primarily reflect differences in proliferation versus differentiation of neural progenitors during cortical development. Here, we have searched for such differences by analysing cerebral organoids from human and chimpanzees using immunohistofluorescence, live imaging, and single-cell transcriptomics. We find that the cytoarchitecture, cell type composition, and neurogenic gene expression programs of humans and chimpanzees are remarkably similar. Notably, however, live imaging of apical progenitor mitosis uncovered a lengthening of prometaphase-metaphase in humans compared to chimpanzees that is specific to proliferating progenitors and not observed in non-neural cells. Consistent with this, the small set of genes more highly expressed in human apical progenitors points to increased proliferative capacity, and the proportion of neurogenic basal progenitors is lower in humans. These subtle differences in cortical progenitors between humans and chimpanzees may have consequences for human neocortex evolution.
英文摘要: Human neocortex expansion likely contributed to the remarkable cognitive abilities of humans. This expansion is thought to primarily reflect differences in proliferation versus differentiation of neural progenitors during cortical development. Here, we have searched for such differences by analysing cerebral organoids from human and chimpanzees using immunohistofluorescence, live imaging, and single-cell transcriptomics. We find that the cytoarchitecture, cell type composition, and neurogenic gene expression programs of humans and chimpanzees are remarkably similar. Notably, however, live imaging of apical progenitor mitosis uncovered a lengthening of prometaphase-metaphase in humans compared to chimpanzees that is specific to proliferating progenitors and not observed in non-neural cells. Consistent with this, the small set of genes more highly expressed in human apical progenitors points to increased proliferative capacity, and the proportion of neurogenic basal progenitors is lower in humans. These subtle differences in cortical progenitors between humans and chimpanzees may have consequences for human neocortex evolution.
刊物名称: ELIFE
英文刊物名称: ELIFE
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学科: Biology
英文学科: Biology
影响因子: 7.725
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论文类别: Article
英文论文类别: Article
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