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论文题目: Ephrin-B3 coordinates timed axon targeting and amygdala spinogenesis for innate fear behaviour
英文论文题目: Ephrin-B3 coordinates timed axon targeting and amygdala spinogenesis for innate fear behaviour
第一作者: Zhu, XN; Liu, XD; Sun, SY; Zhuang, HY; Yang, JY; Henkemeyer, M; Xu, NJ
英文第一作者: Zhu, XN; Liu, XD; Sun, SY; Zhuang, HY; Yang, JY; Henkemeyer, M; Xu, NJ
联系作者: Sun, SY (reprint author), Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Neurol,Inst Neurol, Shanghai 200025, Peoples R China.
英文联系作者: Sun, SY (reprint author), Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Neurol,Inst Neurol, Shanghai 200025, Peoples R China.
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发表年度: 2016
卷: 7
期:
页码: 11096
摘要: Innate emotion response to environmental stimuli is a fundamental brain function that is controlled by specific neural circuits. Dysfunction of early emotional circuits may lead to neurodevelopmental disorders such as autism and schizophrenia. However, how the functional circuits are formed to prime initial emotional behaviours remain elusive. We reveal here using gene-targeted mutations an essential role for ephrin-B3 ligand-like activity in the development of innate fear in the neonatal brain. We further demonstrate that ephrin-B3 controls axon targeting and coordinates spinogenesis and neuronal activity within the amygdala. The morphological and behavioural abnormalities in ephrin-B3 mutant mice are rescued by conditional knock-in of wild-type ephrin-B3 during the critical period when axon targeting and fear responses are initiated. Our results thus define a key axonal molecule that participates in the wiring of amygdala circuits and helps bring about fear emotion during the important adolescence period.
英文摘要: Innate emotion response to environmental stimuli is a fundamental brain function that is controlled by specific neural circuits. Dysfunction of early emotional circuits may lead to neurodevelopmental disorders such as autism and schizophrenia. However, how the functional circuits are formed to prime initial emotional behaviours remain elusive. We reveal here using gene-targeted mutations an essential role for ephrin-B3 ligand-like activity in the development of innate fear in the neonatal brain. We further demonstrate that ephrin-B3 controls axon targeting and coordinates spinogenesis and neuronal activity within the amygdala. The morphological and behavioural abnormalities in ephrin-B3 mutant mice are rescued by conditional knock-in of wild-type ephrin-B3 during the critical period when axon targeting and fear responses are initiated. Our results thus define a key axonal molecule that participates in the wiring of amygdala circuits and helps bring about fear emotion during the important adolescence period.
刊物名称: NATURE COMMUNICATIONS
英文刊物名称: NATURE COMMUNICATIONS
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学科: Multidisciplinary Sciences
英文学科: Multidisciplinary Sciences
影响因子: 12.124
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论文类别: Article
英文论文类别: Article
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