论文库首页  论文库
 
论文编号:
论文题目: Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells
英文论文题目: Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells
第一作者: Chen, Q; Zhang, H; Liu, Y; Adams, S; Eilken, H; Stehling, M; Corada, M; Dejana, E; Zhou, B; Adams, RH
英文第一作者: Chen, Q; Zhang, H; Liu, Y; Adams, S; Eilken, H; Stehling, M; Corada, M; Dejana, E; Zhou, B; Adams, RH
联系作者: Adams, RH (reprint author), Univ Munster, Dept Tissue Morphogenesis, Fac Med, Max Planck Inst Mol Biomed, D-48149 Munster, Germany.
英文联系作者: Adams, RH (reprint author), Univ Munster, Dept Tissue Morphogenesis, Fac Med, Max Planck Inst Mol Biomed, D-48149 Munster, Germany.
外单位作者单位:
英文外单位作者单位:
发表年度: 2016
卷: 7
期:
页码: 12422
摘要: Mural cells of the vessel wall, namely pericytes and vascular smooth muscle cells, are essential for vascular integrity. The developmental sources of these cells and molecular mechanisms controlling their progenitors in the heart are only partially understood. Here we show that endocardial endothelial cells are progenitors of pericytes and vascular smooth muscle cells in the murine embryonic heart. Endocardial cells undergo endothelial-mesenchymal transition and convert into primitive mesenchymal progenitors expressing the platelet-derived growth factor receptors, PDGFR alpha and PDGFR beta. These progenitors migrate into the myocardium, differentiate and assemble the wall of coronary vessels, which requires canonical Wnt signalling involving Frizzled4, beta-catenin and endothelial cell-derived Wnt ligands. Our findings identify a novel and unexpected population of progenitors for coronary mural cells with potential relevance for heart function and disease conditions.
英文摘要: Mural cells of the vessel wall, namely pericytes and vascular smooth muscle cells, are essential for vascular integrity. The developmental sources of these cells and molecular mechanisms controlling their progenitors in the heart are only partially understood. Here we show that endocardial endothelial cells are progenitors of pericytes and vascular smooth muscle cells in the murine embryonic heart. Endocardial cells undergo endothelial-mesenchymal transition and convert into primitive mesenchymal progenitors expressing the platelet-derived growth factor receptors, PDGFR alpha and PDGFR beta. These progenitors migrate into the myocardium, differentiate and assemble the wall of coronary vessels, which requires canonical Wnt signalling involving Frizzled4, beta-catenin and endothelial cell-derived Wnt ligands. Our findings identify a novel and unexpected population of progenitors for coronary mural cells with potential relevance for heart function and disease conditions.
刊物名称: NATURE COMMUNICATIONS
英文刊物名称: NATURE COMMUNICATIONS
论文全文:
英文论文全文:
全文链接:
其它备注:
英文其它备注:
学科: Multidisciplinary Sciences
英文学科: Multidisciplinary Sciences
影响因子: 12.124
第一作者所在部门:
英文第一作者所在部门:
论文出处:
英文论文出处:
论文类别: Article
英文论文类别: Article
参与作者:
英文参与作者:
 
2014 中国科学院上海生命科学研究院 版权所有