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论文题目: USP21 prevents the generation of T-helper-1-like Treg cells
英文论文题目: USP21 prevents the generation of T-helper-1-like Treg cells
第一作者: Li, YY; Lu, Y; Wang, SW; Han, ZJ; Zhu, FX; Ni, YM; Liang, R; Zhang, Y; Leng, QB; Wei, G; Shi, GC; Zhu, RH; Li, D; Wang, HK; Zheng, SG; Xu, HX; Tsun, A; Li, B
英文第一作者: Li, YY; Lu, Y; Wang, SW; Han, ZJ; Zhu, FX; Ni, YM; Liang, R; Zhang, Y; Leng, QB; Wei, G; Shi, GC; Zhu, RH; Li, D; Wang, HK; Zheng, SG; Xu, HX; Tsun, A; Li, B
联系作者: Li, B (reprint author), Chinese Acad Sci, Key Lab Mol Virol & Immunol, CAS Ctr Excellence Mol Cell Sci, Unit Mol Immunol,Inst Pasteur Shanghai,Shanghai I, Shanghai 200025, Peoples R China.
英文联系作者: Li, B (reprint author), Chinese Acad Sci, Key Lab Mol Virol & Immunol, CAS Ctr Excellence Mol Cell Sci, Unit Mol Immunol,Inst Pasteur Shanghai,Shanghai I, Shanghai 200025, Peoples R China.
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发表年度: 2016
卷: 7
期:
页码: 13559
摘要: FOXP3(+) Regulatory T (Treg) cells play a key role in the maintenance of immune homeostasis and tolerance. Disruption of Foxp3 expression results in the generation of instable Treg cells and acquisition of effector T-cell-like function. Here we report that the E3 deubiquitinase USP21 prevents the depletion of FOXP3 at the protein level and restricts the generation of T-helper-1-like Treg cells. Mice depleted of Usp21 specifically in Treg cells display immune disorders characterized by spontaneous T-cell activation and excessive T-helper type 1 (Th1) skewing of Treg cells into Th1-like Treg cells. USP21 stabilizes FOXP3 protein by mediating its deubiquitination and maintains the expression of Treg signature genes. Our results demonstrate how USP21 prevents FOXP3 protein depletion and controls Treg lineage stability in vivo.
英文摘要: FOXP3(+) Regulatory T (Treg) cells play a key role in the maintenance of immune homeostasis and tolerance. Disruption of Foxp3 expression results in the generation of instable Treg cells and acquisition of effector T-cell-like function. Here we report that the E3 deubiquitinase USP21 prevents the depletion of FOXP3 at the protein level and restricts the generation of T-helper-1-like Treg cells. Mice depleted of Usp21 specifically in Treg cells display immune disorders characterized by spontaneous T-cell activation and excessive T-helper type 1 (Th1) skewing of Treg cells into Th1-like Treg cells. USP21 stabilizes FOXP3 protein by mediating its deubiquitination and maintains the expression of Treg signature genes. Our results demonstrate how USP21 prevents FOXP3 protein depletion and controls Treg lineage stability in vivo.
刊物名称: NATURE COMMUNICATIONS
英文刊物名称: NATURE COMMUNICATIONS
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学科: Multidisciplinary Sciences
英文学科: Multidisciplinary Sciences
影响因子: 12.124
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论文类别: Article
英文论文类别: Article
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