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论文题目: Genetic lineage tracing identifies endocardial origin of liver vasculature
英文论文题目: Genetic lineage tracing identifies endocardial origin of liver vasculature
第一作者: Zhang, H; Pu, WJ; Tian, XY; Huang, XZ; He, LJ; Liu, QZ; Li, Y; Zhang, LB; He, L; Liu, K; Gillich, A; Zhou, B
英文第一作者: Zhang, H; Pu, WJ; Tian, XY; Huang, XZ; He, LJ; Liu, QZ; Li, Y; Zhang, LB; He, L; Liu, K; Gillich, A; Zhou, B
联系作者: Zhou, B (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab, Inst Nutr Sci,Grad Sch, Shanghai, Peoples R China.
英文联系作者: Zhou, B (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab, Inst Nutr Sci,Grad Sch, Shanghai, Peoples R China.
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发表年度: 2016
卷: 48
期: 5
页码: 537-+
摘要: The hepatic vasculature is essential for liver development, homeostasis and regeneration, yet the developmental program of hepatic vessel formation and the embryonic origin of the liver vasculature remain unknown. Here we show in mouse that endocardial cells form a primitive vascular plexus surrounding the liver bud and subsequently contribute to a substantial portion of the liver vasculature. Using intersectional genetics, we demonstrate that the endocardium of the sinus venosus is a source for the hepatic plexus. Inhibition of endocardial angiogenesis results in reduced endocardial contribution to the liver vasculature and defects in liver organogenesis. We conclude that a substantial portion of liver vessels derives from the endocardium and shares a common developmental origin with coronary arteries.
英文摘要: The hepatic vasculature is essential for liver development, homeostasis and regeneration, yet the developmental program of hepatic vessel formation and the embryonic origin of the liver vasculature remain unknown. Here we show in mouse that endocardial cells form a primitive vascular plexus surrounding the liver bud and subsequently contribute to a substantial portion of the liver vasculature. Using intersectional genetics, we demonstrate that the endocardium of the sinus venosus is a source for the hepatic plexus. Inhibition of endocardial angiogenesis results in reduced endocardial contribution to the liver vasculature and defects in liver organogenesis. We conclude that a substantial portion of liver vessels derives from the endocardium and shares a common developmental origin with coronary arteries.
刊物名称: NATURE GENETICS
英文刊物名称: NATURE GENETICS
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学科: Genetics & Heredity
英文学科: Genetics & Heredity
影响因子: 27.959
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论文类别: Article
英文论文类别: Article
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