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论文题目: Beyond transcription factors: how oncogenic signalling reshapes the epigenetic landscape
英文论文题目: Beyond transcription factors: how oncogenic signalling reshapes the epigenetic landscape
第一作者: Liu, F; Wang, L; Perna, F; Nimer, SD
英文第一作者: Liu, F; Wang, L; Perna, F; Nimer, SD
联系作者: Nimer, SD (reprint author), Univ Miami, Dept Biochem & Mol Biol, Miami, FL 33136 USA.
英文联系作者: Nimer, SD (reprint author), Univ Miami, Dept Biochem & Mol Biol, Miami, FL 33136 USA.
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发表年度: 2016
卷: 16
期: 6
页码: 359-372
摘要: Cancer, once thought to be caused largely by genetic alterations, is now considered to be a mixed genetic and epigenetic disease. The epigenetic landscape, which is dictated by covalent DNA and histone modifications, is profoundly altered in transformed cells. These abnormalities may arise from mutations in, or altered expression of, chromatin modifiers. Recent reports on the interplay between cellular signalling pathways and chromatin modifications add another layer of complexity to the already complex regulation of the epigenome. In this Review, we discuss these new studies and how the insights they provide can contribute to a better understanding of the molecular pathogenesis of neoplasia.
英文摘要: Cancer, once thought to be caused largely by genetic alterations, is now considered to be a mixed genetic and epigenetic disease. The epigenetic landscape, which is dictated by covalent DNA and histone modifications, is profoundly altered in transformed cells. These abnormalities may arise from mutations in, or altered expression of, chromatin modifiers. Recent reports on the interplay between cellular signalling pathways and chromatin modifications add another layer of complexity to the already complex regulation of the epigenome. In this Review, we discuss these new studies and how the insights they provide can contribute to a better understanding of the molecular pathogenesis of neoplasia.
刊物名称: NATURE REVIEWS CANCER
英文刊物名称: NATURE REVIEWS CANCER
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学科: Oncology
英文学科: Oncology
影响因子: 37.147
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论文类别: Article
英文论文类别: Article
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