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论文题目: Towards Tyrosine Metabolism in Esophageal Squamous Cell Carcinoma
英文论文题目: Towards Tyrosine Metabolism in Esophageal Squamous Cell Carcinoma
第一作者: Cheng, J; Zheng, GY; Jin, H; Gao, XF
英文第一作者: Cheng, J; Zheng, GY; Jin, H; Gao, XF
联系作者: Zheng, GY; Gao, XF (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai 200031, Peoples R China.
英文联系作者: Zheng, GY; Gao, XF (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai 200031, Peoples R China.
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发表年度: 2017
卷: 20
期: 2
页码: 133-139
摘要: Background: Esophageal Squamous Cell Carcinoma (ESCC) is a common malignant tumor in China, which causes about 200,000 deaths each year. Sensitive biomarkers are helpful to diagnose the disease in early stage. Methods: To identify biomarkers of ESCC and elucidate underlying mechanism of the disease, a targeted metabolomics strategy based on liquid chromatography- tandem mass spectrometry (LCMS/MS) has been implemented to explore tyrosine metabolism from 40 ESCC patients and 27 healthy controls. Results: Four metabolites, i.e. phenylalanine, 4-hydroxyphenyllactic acid, 3,4-dihydroxyphenylalanine, and 3,4-dihydroxyphenylacetic acid were identified as diagnostic biomarkers for ESCC patients. Based on these biomarkers, a prediction model was constructed for ESCC diagnosis. The analysis of receiver operating characteristic (ROC) curve confirmed its effectiveness of the model. Conclusion: Our results reveal that tyrosine metabolism is disturbed in ESCC patients and the metabolites involved in tyrosine pathway can be used as diagnostic biomarkers of the disease. Findings of this study can help investigate pathogenesis of ESCC and facilitate understanding mechanism of the disease.
英文摘要: Background: Esophageal Squamous Cell Carcinoma (ESCC) is a common malignant tumor in China, which causes about 200,000 deaths each year. Sensitive biomarkers are helpful to diagnose the disease in early stage. Methods: To identify biomarkers of ESCC and elucidate underlying mechanism of the disease, a targeted metabolomics strategy based on liquid chromatography- tandem mass spectrometry (LCMS/MS) has been implemented to explore tyrosine metabolism from 40 ESCC patients and 27 healthy controls. Results: Four metabolites, i.e. phenylalanine, 4-hydroxyphenyllactic acid, 3,4-dihydroxyphenylalanine, and 3,4-dihydroxyphenylacetic acid were identified as diagnostic biomarkers for ESCC patients. Based on these biomarkers, a prediction model was constructed for ESCC diagnosis. The analysis of receiver operating characteristic (ROC) curve confirmed its effectiveness of the model. Conclusion: Our results reveal that tyrosine metabolism is disturbed in ESCC patients and the metabolites involved in tyrosine pathway can be used as diagnostic biomarkers of the disease. Findings of this study can help investigate pathogenesis of ESCC and facilitate understanding mechanism of the disease.
刊物名称: COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
英文刊物名称: COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
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学科: Biochemical Research Methods; Chemistry, Applied; Pharmacology & Pharmacy
英文学科: Biochemical Research Methods; Chemistry, Applied; Pharmacology & Pharmacy
影响因子: 0.952
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论文类别: Article
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