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论文题目: Identification of a cytokine-cytokine receptor interaction gene signature for predicting clinical outcomes in patients with colorectal cancer
英文论文题目: Identification of a cytokine-cytokine receptor interaction gene signature for predicting clinical outcomes in patients with colorectal cancer
第一作者: Dong, CP; Wang, X; Xu, HL; Zhan, XH; Ren, H; Liu, ZH; Liu, G; Liu, L
英文第一作者: Dong, CP; Wang, X; Xu, HL; Zhan, XH; Ren, H; Liu, ZH; Liu, G; Liu, L
联系作者: Liu, G; Liu, L (reprint author), Fudan Univ, Inst Biomed Sci, Shanghai Publ Hlth Clin Ctr, 131 Dongan Rd, Shanghai 200032, Peoples R China.
英文联系作者: Liu, G; Liu, L (reprint author), Fudan Univ, Inst Biomed Sci, Shanghai Publ Hlth Clin Ctr, 131 Dongan Rd, Shanghai 200032, Peoples R China.
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发表年度: 2017
卷: 10
期: 6
页码: 9009-+
摘要: The role of chronic inflammation in colorectal cancer development and progression is an issue of high interest. Cytokine and cytokine receptor interaction networks are regarded as crucial aspects of inflammation and tumor immunology, particularly for colorectal cancer. However, cytokine expression pattern genes have never been established for colorectal cancer prognosis prediction. Using a gene-mining approach with TCGA and GEO database, we identified an eight-gene signature in cytokine and cytokine receptor interaction signaling pathway, which is significantly associated with the colorectal patients' prognosis. Based on this eight-gene model, we classified patients for training sets into two groups, patients that with high-risk and low risk group, due to significant difference on overall survival (HR=2.72; P=0.00001) and RFS (HR=1.87; P=0.0007). The prognostic value of these eight cytokine-cytokine receptor interaction gene panels was validated in independent testing sets. Our results might provide an aid for colorectal cancer prognosis evaluation and preselect patients suitable for more effective therapy strategies.
英文摘要: The role of chronic inflammation in colorectal cancer development and progression is an issue of high interest. Cytokine and cytokine receptor interaction networks are regarded as crucial aspects of inflammation and tumor immunology, particularly for colorectal cancer. However, cytokine expression pattern genes have never been established for colorectal cancer prognosis prediction. Using a gene-mining approach with TCGA and GEO database, we identified an eight-gene signature in cytokine and cytokine receptor interaction signaling pathway, which is significantly associated with the colorectal patients' prognosis. Based on this eight-gene model, we classified patients for training sets into two groups, patients that with high-risk and low risk group, due to significant difference on overall survival (HR=2.72; P=0.00001) and RFS (HR=1.87; P=0.0007). The prognostic value of these eight cytokine-cytokine receptor interaction gene panels was validated in independent testing sets. Our results might provide an aid for colorectal cancer prognosis evaluation and preselect patients suitable for more effective therapy strategies.
刊物名称: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
英文刊物名称: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
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学科: Medicine, Research & Experimental
英文学科: Medicine, Research & Experimental
影响因子: 1.069
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论文类别: Article
英文论文类别: Article
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