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论文题目: Adaptation of human skin color in various populations
英文论文题目: Adaptation of human skin color in various populations
第一作者: Deng, L; Xu, SH
英文第一作者: Deng, L; Xu, SH
联系作者: Xu, SH (reprint author), Chinese Acad Sci, Key Lab Computat Biol,Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol PICB, Shanghai 200031, Peoples R China.
英文联系作者: Xu, SH (reprint author), Chinese Acad Sci, Key Lab Computat Biol,Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol PICB, Shanghai 200031, Peoples R China.
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发表年度: 2017
卷: 155
期:
页码: 1
摘要: Background: Skin color is a well-recognized adaptive trait and has been studied extensively in humans. Understanding the genetic basis of adaptation of skin color in various populations has many implications in human evolution and medicine. Discussion: Impressive progress has been made recently to identify genes associated with skin color variation in a wide range of geographical and temporal populations. In this review, we discuss what is currently known about the genetics of skin color variation. We enumerated several cases of skin color adaptation in global modern humans and archaic hominins, and illustrated why, when, and how skin color adaptation occurred in different populations. Finally, we provided a summary of the candidate loci associated with pigmentation, which could be a valuable reference for further evolutionary and medical studies. Conclusion: Previous studies generally indicated a complex genetic mechanism underlying the skin color variation, expanding our understanding of the role of population demographic history and natural selection in shaping genetic and phenotypic diversity in humans. Future work is needed to dissect the genetic architecture of skin color adaptation in numerous ethnic minority groups around the world, which remains relatively obscure compared with that of major continental groups, and to unravel the exact genetic basis of skin color adaptation.
英文摘要: Background: Skin color is a well-recognized adaptive trait and has been studied extensively in humans. Understanding the genetic basis of adaptation of skin color in various populations has many implications in human evolution and medicine. Discussion: Impressive progress has been made recently to identify genes associated with skin color variation in a wide range of geographical and temporal populations. In this review, we discuss what is currently known about the genetics of skin color variation. We enumerated several cases of skin color adaptation in global modern humans and archaic hominins, and illustrated why, when, and how skin color adaptation occurred in different populations. Finally, we provided a summary of the candidate loci associated with pigmentation, which could be a valuable reference for further evolutionary and medical studies. Conclusion: Previous studies generally indicated a complex genetic mechanism underlying the skin color variation, expanding our understanding of the role of population demographic history and natural selection in shaping genetic and phenotypic diversity in humans. Future work is needed to dissect the genetic architecture of skin color adaptation in numerous ethnic minority groups around the world, which remains relatively obscure compared with that of major continental groups, and to unravel the exact genetic basis of skin color adaptation.
刊物名称: HEREDITAS
英文刊物名称: HEREDITAS
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学科: Genetics & Heredity
英文学科: Genetics & Heredity
影响因子: 1.345
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论文类别: Article
英文论文类别: Article
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