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论文题目: Common variants in GRIK4 and major depressive disorder: An association study in the Chinese Han population
英文论文题目: Common variants in GRIK4 and major depressive disorder: An association study in the Chinese Han population
第一作者: Ren, DC; Bi, Y; Xu, F; Niu, WB; Zhang, R; Hu, JX; Guo, ZM; Wu, X; Cao, YF; Huang, XY; Yang, FP; Wang, L; Li, WD; Xu, YF; He, L; Yu, T; He, G; Li, XW
英文第一作者: Ren, DC; Bi, Y; Xu, F; Niu, WB; Zhang, R; Hu, JX; Guo, ZM; Wu, X; Cao, YF; Huang, XY; Yang, FP; Wang, L; Li, WD; Xu, YF; He, L; Yu, T; He, G; Li, XW
联系作者: Yu, T; He, G; Li, XW (reprint author), Shanghai Jiao Tong Univ, Minist Educ, Bio X Inst, Key Lab Genet Dev & Neuropsychiat Disorders, 1954 Huashan Rd, Shanghai 200030, Peoples R China.
英文联系作者: Yu, T; He, G; Li, XW (reprint author), Shanghai Jiao Tong Univ, Minist Educ, Bio X Inst, Key Lab Genet Dev & Neuropsychiat Disorders, 1954 Huashan Rd, Shanghai 200030, Peoples R China.
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发表年度: 2017
卷: 653
期:
页码: 239-243
摘要: Major depressive disorder (MDD) is a common and complex mental disorder. Recent studies found that genetic variants located in GRIK4, which encoded glutamate ionotropic receptor kainate type subunit 4, was associated with the MDD. In this study, we intended to investigate whether GRIK4 gene was associated with MDD. So five single nucleotide polymorphisms (SNPs) were selected and genotyped (rs79526501, rs11218016, rs4582985, rs6589847, rs56275759) in 568 MDD patients and 846 healthy controls from Chinese Han population. The results showed that rs56275759 demonstrated statistically significant differences between MDD patients and control subjects both in allelic frequencies (p value = 0.011) and genotypic frequencies (p value = 0.029). Rs4582985 was excluded from the further analysis for its deviation from the Hardy-Weinberg equilibrium. Strong linkage disequilibrium (LD) was found among rs11218016, rs6589847 and rs56275759, and this block was significantly associated with MDD. In summary, our results firstly indicated that rs56275759 of GRIK4 gene might be associated with MDD in Chinese Han population.
英文摘要: Major depressive disorder (MDD) is a common and complex mental disorder. Recent studies found that genetic variants located in GRIK4, which encoded glutamate ionotropic receptor kainate type subunit 4, was associated with the MDD. In this study, we intended to investigate whether GRIK4 gene was associated with MDD. So five single nucleotide polymorphisms (SNPs) were selected and genotyped (rs79526501, rs11218016, rs4582985, rs6589847, rs56275759) in 568 MDD patients and 846 healthy controls from Chinese Han population. The results showed that rs56275759 demonstrated statistically significant differences between MDD patients and control subjects both in allelic frequencies (p value = 0.011) and genotypic frequencies (p value = 0.029). Rs4582985 was excluded from the further analysis for its deviation from the Hardy-Weinberg equilibrium. Strong linkage disequilibrium (LD) was found among rs11218016, rs6589847 and rs56275759, and this block was significantly associated with MDD. In summary, our results firstly indicated that rs56275759 of GRIK4 gene might be associated with MDD in Chinese Han population.
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学科: Neurosciences
英文学科: Neurosciences
影响因子: 2.18
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论文类别: Article
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