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论文题目: No association between SLC6A2, SLC6A3, DRD2 polymorphisms and schizophrenia in the Han Chinese population
英文论文题目: No association between SLC6A2, SLC6A3, DRD2 polymorphisms and schizophrenia in the Han Chinese population
第一作者: Bi, Y; Huang, XY; Niu, WB; Chen, SQ; Wu, X; Cao, YF; Zhan, R; Yang, FP; Wang, L; Li, WD; Xu, YF; He, L; Yu, T; Li, XW; He, G
英文第一作者: Bi, Y; Huang, XY; Niu, WB; Chen, SQ; Wu, X; Cao, YF; Zhan, R; Yang, FP; Wang, L; Li, WD; Xu, YF; He, L; Yu, T; Li, XW; He, G
联系作者: Yu, T; Li, XW; He, G (reprint author), Shanghai Jiao Tong Univ, Biox Ctr, 1954 Huashan Rd, Shanghai 200030, Peoples R China.
英文联系作者: Yu, T; Li, XW; He, G (reprint author), Shanghai Jiao Tong Univ, Biox Ctr, 1954 Huashan Rd, Shanghai 200030, Peoples R China.
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发表年度: 2017
卷: 253
期:
页码: 398-400
摘要: This study was intended to ascertain whether SNPs in dopaminergic and serotoninergic pathway genes SLC6A2, SLC6A3 and DRD2 are associated with schizophrenia in Han Chinese people. We conducted a case-control study by genotyping 7 SNPs of the three genes in 1034 schizophrenia patients and 1034 controls. No significant difference in the allelic or genotypic frequency was detected between cases and controls despite one positive haplotype (rs1362621-rs2242446-rs5564). Stratified analysis of gender and gene-gene interaction analysis showed no positive results. In summary, our study denies the major role of these SNPs within the three genes for schizophrenia in Han Chinese.
英文摘要: This study was intended to ascertain whether SNPs in dopaminergic and serotoninergic pathway genes SLC6A2, SLC6A3 and DRD2 are associated with schizophrenia in Han Chinese people. We conducted a case-control study by genotyping 7 SNPs of the three genes in 1034 schizophrenia patients and 1034 controls. No significant difference in the allelic or genotypic frequency was detected between cases and controls despite one positive haplotype (rs1362621-rs2242446-rs5564). Stratified analysis of gender and gene-gene interaction analysis showed no positive results. In summary, our study denies the major role of these SNPs within the three genes for schizophrenia in Han Chinese.
刊物名称: PSYCHIATRY RESEARCH
英文刊物名称: PSYCHIATRY RESEARCH
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学科: Psychiatry
英文学科: Psychiatry
影响因子: 2.528
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论文类别: Article
英文论文类别: Article
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