论文库首页  论文库
 
论文编号:
论文题目: Downregulated miR-29a/b/c during Contact Inhibition Stage Promote 3T3-L1 Adipogenesis by Targeting DNMT3A
英文论文题目: Downregulated miR-29a/b/c during Contact Inhibition Stage Promote 3T3-L1 Adipogenesis by Targeting DNMT3A
第一作者: Zhu, YJ; Zheng, GY; Wang, HC; Jia, YD; Zhang, Y; Tang, YF; Li, WL; Fan, YA; Zhang, XD; Liu, YW; Liu, SH
英文第一作者: Zhu, YJ; Zheng, GY; Wang, HC; Jia, YD; Zhang, Y; Tang, YF; Li, WL; Fan, YA; Zhang, XD; Liu, YW; Liu, SH
联系作者: Liu, SH (reprint author), Henan Prov Orthoped Hosp, Henan Prov Luoyang Orthoped Traumatol Hosp, Luoyang, Henan, Peoples R China.
英文联系作者: Liu, SH (reprint author), Henan Prov Orthoped Hosp, Henan Prov Luoyang Orthoped Traumatol Hosp, Luoyang, Henan, Peoples R China.
外单位作者单位:
英文外单位作者单位:
发表年度: 2017
卷: 12
期: 1
页码: e0170636
摘要: Differentiation of 3T3-L1 cells into adipocytes involves a highly-orchestrated series of events including contact inhibition (CI), clonal expansion, growth arrest, and terminal differentiation. Recent study demonstrated that 3T3-L1 preadipocytes will not be differentiated into mature adipocytes without CI stage, which indicated that CI stage plays an important role during 3T3-L1 adipogenesis. However, the molecular mechanism is not yet fully understood. In the present study, we found that the expression level of miR-29a/b/c was decreased and the expression of DNMT3A was up-regulated during CI stage, respectively. Furthermore, overexpression of miR-29a/b/c during CI stage inhibits adipogenesis significantly but not at other stages. In addition, miR-29a/b/c repressed DNMT3A expression by directly targeting its 3' untranslated region (3' UTR). Our data reveal a novel mechanism of miR-29a/b/c in the regulation of adipogenesis.
英文摘要: Differentiation of 3T3-L1 cells into adipocytes involves a highly-orchestrated series of events including contact inhibition (CI), clonal expansion, growth arrest, and terminal differentiation. Recent study demonstrated that 3T3-L1 preadipocytes will not be differentiated into mature adipocytes without CI stage, which indicated that CI stage plays an important role during 3T3-L1 adipogenesis. However, the molecular mechanism is not yet fully understood. In the present study, we found that the expression level of miR-29a/b/c was decreased and the expression of DNMT3A was up-regulated during CI stage, respectively. Furthermore, overexpression of miR-29a/b/c during CI stage inhibits adipogenesis significantly but not at other stages. In addition, miR-29a/b/c repressed DNMT3A expression by directly targeting its 3' untranslated region (3' UTR). Our data reveal a novel mechanism of miR-29a/b/c in the regulation of adipogenesis.
刊物名称: PLOS ONE
英文刊物名称: PLOS ONE
论文全文:
英文论文全文:
全文链接:
其它备注:
英文其它备注:
学科: Multidisciplinary Sciences
英文学科: Multidisciplinary Sciences
影响因子: 2.806
第一作者所在部门:
英文第一作者所在部门:
论文出处:
英文论文出处:
论文类别: Article
英文论文类别: Article
参与作者:
英文参与作者:
 
2014 中国科学院上海生命科学研究院 版权所有