论文库首页  论文库
 
论文编号:
论文题目: SF3B4 is decreased in pancreatic cancer and inhibits the growth and migration of cancer cells
英文论文题目: SF3B4 is decreased in pancreatic cancer and inhibits the growth and migration of cancer cells
第一作者: Zhou, WT; Ma, N; Jiang, H; Rong, YF; Deng, YZ; Feng, YY; Zhu, HX; Kuang, TT; Lou, WH; Xie, D; Wang, DS
英文第一作者: Zhou, WT; Ma, N; Jiang, H; Rong, YF; Deng, YZ; Feng, YY; Zhu, HX; Kuang, TT; Lou, WH; Xie, D; Wang, DS
联系作者: Xie, D (reprint author), Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Lab Mol Oncol, 320 Yueyang Rd, Shanghai 200031, Peoples R China.
英文联系作者: Xie, D (reprint author), Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Lab Mol Oncol, 320 Yueyang Rd, Shanghai 200031, Peoples R China.
外单位作者单位:
英文外单位作者单位:
发表年度: 2017
卷: 39
期: 3
页码: -
摘要: Splicing factor 3b subunit 4, a critical component of pre-message RNA splicing complex, has been reported to play an important part in the tumorigenesis. However, the expression pattern and biological role of splicing factor 3b subunit 4 in pancreatic cancer have never been investigated. In this study, we found that both the messenger RNA (p < 0.001) and protein level of splicing factor 3b subunit 4 were decreased significantly in pancreatic cancer specimens compared with their adjacent normal tissues. Overexpression of splicing factor 3b subunit 4 in pancreatic cancer cells inhibited cell growth and motility in vitro, while suppressing splicing factor 3b subunit 4 expression promoted the proliferation and migration of pancreatic cancer cells. In addition, splicing factor 3b subunit 4 was found to inhibit the activity of signal transducer and activator of transcription 3 signaling via downregulating the phosphorylation of signal transducer and activator of transcription 3 on a tyrosine residue at position 705. Taken together, these findings demonstrated that splicing factor 3b subunit 4 acted as a suppressive role in pancreatic cancer and indicated that restoring the function of splicing factor 3b subunit 4 might be a strategy for cancer therapy.
英文摘要: Splicing factor 3b subunit 4, a critical component of pre-message RNA splicing complex, has been reported to play an important part in the tumorigenesis. However, the expression pattern and biological role of splicing factor 3b subunit 4 in pancreatic cancer have never been investigated. In this study, we found that both the messenger RNA (p < 0.001) and protein level of splicing factor 3b subunit 4 were decreased significantly in pancreatic cancer specimens compared with their adjacent normal tissues. Overexpression of splicing factor 3b subunit 4 in pancreatic cancer cells inhibited cell growth and motility in vitro, while suppressing splicing factor 3b subunit 4 expression promoted the proliferation and migration of pancreatic cancer cells. In addition, splicing factor 3b subunit 4 was found to inhibit the activity of signal transducer and activator of transcription 3 signaling via downregulating the phosphorylation of signal transducer and activator of transcription 3 on a tyrosine residue at position 705. Taken together, these findings demonstrated that splicing factor 3b subunit 4 acted as a suppressive role in pancreatic cancer and indicated that restoring the function of splicing factor 3b subunit 4 might be a strategy for cancer therapy.
刊物名称: TUMOR BIOLOGY
英文刊物名称: TUMOR BIOLOGY
论文全文:
英文论文全文:
全文链接:
其它备注:
英文其它备注:
学科: Oncology
英文学科: Oncology
影响因子: 3.65
第一作者所在部门:
英文第一作者所在部门:
论文出处:
英文论文出处:
论文类别: Article
英文论文类别: Article
参与作者:
英文参与作者:
 
2014 中国科学院上海生命科学研究院 版权所有