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论文题目: Genetic variants associated with skin aging in the Chinese Han population
英文论文题目: Genetic variants associated with skin aging in the Chinese Han population
第一作者: Gao, WS; Tan, JZ; Huls, A; Ding, AA; Liu, Y; Matsui, MS; Vierkotter, A; Krutmann, J; Schikowski, T; Jin, L; Wang, SJ
英文第一作者: Gao, WS; Tan, JZ; Huls, A; Ding, AA; Liu, Y; Matsui, MS; Vierkotter, A; Krutmann, J; Schikowski, T; Jin, L; Wang, SJ
联系作者: Wang, SJ (reprint author), Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.
英文联系作者: Wang, SJ (reprint author), Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.
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发表年度: 2017
卷: 86
期: 1
页码: 21-29
摘要: Background: The progression and manifestation of human skin aging has a strong genetic basis; however, most of the supporting evidence has been gathered in Caucasian populations. The genetic contribution to the variation in skin aging in non-Caucasian populations is poorly understood. Objective: To investigate the genetic risk factors of relevance for skin aging in East Asians, we conducted the first candidate gene study for signs of skin aging in Han Chinese. Methods: We collected skin aging and genotype data in 502 female Han Chinese from the Taizhou cohort. We evaluated skin aging by the validated skin aging score SCINEXA (TM). Confounding factors were assessed through a questionnaire. We obtained the genotype data for 21 candidate SNPs and for a further 509 SNPs from 16 related candidate genes. Associations were tested by linear and logistic regression analyses and adjusted for potential confounders. Results: Our candidate study found a significant association between SNP rs2066853 in exon 10 of the aryl hydrocarbon receptor gene AHR and crow's feet. In addition, we found a significant association between SNP rs10733310 in intron 5 of BNC2 and pigment spots on the arms, and between SNP rs11979919, 3 kb downstream of COL1A2, and laxity of eyelids. Conclusions: Our results identified genetic risk factors for signs of skin aging (pigmentation, wrinkles or laxity) in Han Chinese. We also found that the manifestation of skin aging is further modified by anatomical site. Together with previous work, our results also suggest that different genetic variants could be responsible for distinct skin aging signs characteristic of Caucasians compared to East Asians.
英文摘要: Background: The progression and manifestation of human skin aging has a strong genetic basis; however, most of the supporting evidence has been gathered in Caucasian populations. The genetic contribution to the variation in skin aging in non-Caucasian populations is poorly understood. Objective: To investigate the genetic risk factors of relevance for skin aging in East Asians, we conducted the first candidate gene study for signs of skin aging in Han Chinese. Methods: We collected skin aging and genotype data in 502 female Han Chinese from the Taizhou cohort. We evaluated skin aging by the validated skin aging score SCINEXA (TM). Confounding factors were assessed through a questionnaire. We obtained the genotype data for 21 candidate SNPs and for a further 509 SNPs from 16 related candidate genes. Associations were tested by linear and logistic regression analyses and adjusted for potential confounders. Results: Our candidate study found a significant association between SNP rs2066853 in exon 10 of the aryl hydrocarbon receptor gene AHR and crow's feet. In addition, we found a significant association between SNP rs10733310 in intron 5 of BNC2 and pigment spots on the arms, and between SNP rs11979919, 3 kb downstream of COL1A2, and laxity of eyelids. Conclusions: Our results identified genetic risk factors for signs of skin aging (pigmentation, wrinkles or laxity) in Han Chinese. We also found that the manifestation of skin aging is further modified by anatomical site. Together with previous work, our results also suggest that different genetic variants could be responsible for distinct skin aging signs characteristic of Caucasians compared to East Asians.
刊物名称: JOURNAL OF DERMATOLOGICAL SCIENCE
英文刊物名称: JOURNAL OF DERMATOLOGICAL SCIENCE
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学科: Dermatology
英文学科: Dermatology
影响因子: 3.733
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论文类别: Article
英文论文类别: Article
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