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论文题目: Ablation of PPP1R3G reduces glycogen deposition and mitigates high-fat diet induced obesity
英文论文题目: Ablation of PPP1R3G reduces glycogen deposition and mitigates high-fat diet induced obesity
第一作者: Zhang, YX; Gu, J; Wang, L; Zhao, ZL; Pan, Y; Chen, Y
英文第一作者: Zhang, YX; Gu, J; Wang, L; Zhao, ZL; Pan, Y; Chen, Y
联系作者: Chen, Y (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, 320 Yueyang Rd,New Life Sci Bldg,A2214, Shanghai 200031, Peoples R China.
英文联系作者: Chen, Y (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, 320 Yueyang Rd,New Life Sci Bldg,A2214, Shanghai 200031, Peoples R China.
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发表年度: 2017
卷: 439
期: C
页码: 133-140
摘要: Glycogen and triglyceride are two major forms of energy storage in the body and provide the fuel during different phases of food deprivation. However, how glycogen metabolism is linked to fat deposition in adipose tissue has not been clearly characterized. We generated a mouse model with whole-body deletion of PPP1R3G, a glycogen-targeting subunit of protein phosphatase-1 required for glycogen synthesis. Upon feeding with high-fat diet, the body weight and fat composition are significantly reduced in the PPP1R3G(-/-) mice compared to the wild type controls. The metabolic rate of the mice as measured by O-2 consumption and CO2 production is accelerated by PPPIR3G deletion. The high-fat diet-induced liver steatosis is also slightly relieved by PPP1R3G deletion. The glycogen level in adipose tissue is reduced by PPP1R3G deletion. In 3T3L1 cells, overexpression of PPPIR3G leads to increases of both glycogen and triglyceride levels. In conclusion, our study indicates that glycogen is actively involved in fat accumulation in adipose tissue and obesity development upon high-fat diet. Our study also suggests that PPP1R3G is an important player that links glycogen metabolism to lipid metabolism in vivo.
英文摘要: Glycogen and triglyceride are two major forms of energy storage in the body and provide the fuel during different phases of food deprivation. However, how glycogen metabolism is linked to fat deposition in adipose tissue has not been clearly characterized. We generated a mouse model with whole-body deletion of PPP1R3G, a glycogen-targeting subunit of protein phosphatase-1 required for glycogen synthesis. Upon feeding with high-fat diet, the body weight and fat composition are significantly reduced in the PPP1R3G(-/-) mice compared to the wild type controls. The metabolic rate of the mice as measured by O-2 consumption and CO2 production is accelerated by PPPIR3G deletion. The high-fat diet-induced liver steatosis is also slightly relieved by PPP1R3G deletion. The glycogen level in adipose tissue is reduced by PPP1R3G deletion. In 3T3L1 cells, overexpression of PPPIR3G leads to increases of both glycogen and triglyceride levels. In conclusion, our study indicates that glycogen is actively involved in fat accumulation in adipose tissue and obesity development upon high-fat diet. Our study also suggests that PPP1R3G is an important player that links glycogen metabolism to lipid metabolism in vivo.
刊物名称: MOLECULAR AND CELLULAR ENDOCRINOLOGY
英文刊物名称: MOLECULAR AND CELLULAR ENDOCRINOLOGY
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学科: Cell Biology; Endocrinology & Metabolism
英文学科: Cell Biology; Endocrinology & Metabolism
影响因子: 3.754
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论文类别: Article
英文论文类别: Article
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