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论文题目: Association of a Gain-of-Function Variant in LGR4 with Central Obesity
英文论文题目: Association of a Gain-of-Function Variant in LGR4 with Central Obesity
第一作者: Zou, YY; Ning, TL; Shi, J; Chen, MP; Ding, L; Huang, Y; Kauderer, S; Xu, M; Cui, B; Bi, YF; Liu, SM; Hong, J; Liu, RX; Ning, G; Wang, JQ
英文第一作者: Zou, YY; Ning, TL; Shi, J; Chen, MP; Ding, L; Huang, Y; Kauderer, S; Xu, M; Cui, B; Bi, YF; Liu, SM; Hong, J; Liu, RX; Ning, G; Wang, JQ
联系作者: Ning, G (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Lab Endocrinol & Metab, Shanghai, Peoples R China.
英文联系作者: Ning, G (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Lab Endocrinol & Metab, Shanghai, Peoples R China.
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发表年度: 2017
卷: 25
期: 1
页码: 252-260
摘要: Objective: To determine the relationship of the gain-of-function variant A750T in leucine-rich repeat containing G protein-coupled receptor 4 (LGR4) with central obesity and related metabolic phenotypes. Methods: The LGR4 A750T (c. 2248 G > A) variant was detected by Sanger sequencing in a discovery young population and a validation community-based population with obesity from eastern China. Fat indices determined by anthropometry and computed tomography scans and clinical biochemical measurements were collected for association analysis. Results: LGR4 A750T was significantly correlated with waist circumference (P = 0.030) and waist-to-height ratio (P < 0.001) in the young cohort (N = 594) and with waist-to-hip ratio (P 5 0.013) in the community population (N = 1067). Combined analysis showed a significant correlation of the variant with waist circumference (P < 0.001) and waist-to-hip ratio (P = 0.021). Moreover, the variant had a remarkable correlation with abdominal visceral fat area (P = 0.004) and was associated with 2-h plasma insulin (P = 0.009) and the Matsuda index (P = 0.027) after an oral glucose tolerance test in young subjects with obesity. Conclusions: The LGR4 A750T variant may contribute to central obesity characterized by abdominal visceral fat accumulation.
英文摘要: Objective: To determine the relationship of the gain-of-function variant A750T in leucine-rich repeat containing G protein-coupled receptor 4 (LGR4) with central obesity and related metabolic phenotypes. Methods: The LGR4 A750T (c. 2248 G > A) variant was detected by Sanger sequencing in a discovery young population and a validation community-based population with obesity from eastern China. Fat indices determined by anthropometry and computed tomography scans and clinical biochemical measurements were collected for association analysis. Results: LGR4 A750T was significantly correlated with waist circumference (P = 0.030) and waist-to-height ratio (P < 0.001) in the young cohort (N = 594) and with waist-to-hip ratio (P 5 0.013) in the community population (N = 1067). Combined analysis showed a significant correlation of the variant with waist circumference (P < 0.001) and waist-to-hip ratio (P = 0.021). Moreover, the variant had a remarkable correlation with abdominal visceral fat area (P = 0.004) and was associated with 2-h plasma insulin (P = 0.009) and the Matsuda index (P = 0.027) after an oral glucose tolerance test in young subjects with obesity. Conclusions: The LGR4 A750T variant may contribute to central obesity characterized by abdominal visceral fat accumulation.
刊物名称: OBESITY
英文刊物名称: OBESITY
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学科: Endocrinology & Metabolism; Nutrition & Dietetics
英文学科: Endocrinology & Metabolism; Nutrition & Dietetics
影响因子: 3.873
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论文类别: Article
英文论文类别: Article
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