论文库首页  论文库
 
论文编号:
论文题目: Synthesis of polypyrrole nanowires with positive effect on MC3T3-E1 cell functions through electrical stimulation
英文论文题目: Synthesis of polypyrrole nanowires with positive effect on MC3T3-E1 cell functions through electrical stimulation
第一作者: He, Y; Wang, SH; Mu, J; Dai, LF; Zhang, Z; Sun, YA; Shi, W; Ge, DT
英文第一作者: He, Y; Wang, SH; Mu, J; Dai, LF; Zhang, Z; Sun, YA; Shi, W; Ge, DT
联系作者: Mu, J (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Max Planck Partner Inst Computat Biol, Shanghai 200031, Peoples R China.
英文联系作者: Mu, J (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Max Planck Partner Inst Computat Biol, Shanghai 200031, Peoples R China.
外单位作者单位:
英文外单位作者单位:
发表年度: 2017
卷: 71
期:
页码: 43-50
摘要: Conducting polymer polypyrrole (PPy) possesses good biocompatibility and conductivity and has been used as functional coatings in bone tissue regeneration. In this study, a cholic acid doped PPy nanowires (PPy NWs) coating was electrochemically polymerized on the surface of titanium (Ti). The porous intertwined PPy NWs coating exhibited excellent electrical conductivity and electrochemical activity, better hydrophilicity and higher surface energy. In vitro cell experiments demonstrated that the PPy NWs coating together with a 10 A substrate-mediate electrical stimulation (ES) was capable to positive regulate the functions of MCT3-E1 such as cell adhesion, proliferation and differentiation. Further long-term functions of cell tests including alkaline phosphatase (ALP) activity, bone-carboxyglutamic acid-containing protein (BGP) and calcium deposition were all thoroughly increased. These confirmed that the combination of PPy NWs and ES could accelerate MC3T3-E1 cells mature and osteogenesis. Hence, the PPy NWs coating was an electro bioactive coating and may have potential applications in the treatment of bone damage repairing and regeneration with ES.
英文摘要: Conducting polymer polypyrrole (PPy) possesses good biocompatibility and conductivity and has been used as functional coatings in bone tissue regeneration. In this study, a cholic acid doped PPy nanowires (PPy NWs) coating was electrochemically polymerized on the surface of titanium (Ti). The porous intertwined PPy NWs coating exhibited excellent electrical conductivity and electrochemical activity, better hydrophilicity and higher surface energy. In vitro cell experiments demonstrated that the PPy NWs coating together with a 10 A substrate-mediate electrical stimulation (ES) was capable to positive regulate the functions of MCT3-E1 such as cell adhesion, proliferation and differentiation. Further long-term functions of cell tests including alkaline phosphatase (ALP) activity, bone-carboxyglutamic acid-containing protein (BGP) and calcium deposition were all thoroughly increased. These confirmed that the combination of PPy NWs and ES could accelerate MC3T3-E1 cells mature and osteogenesis. Hence, the PPy NWs coating was an electro bioactive coating and may have potential applications in the treatment of bone damage repairing and regeneration with ES.
刊物名称: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
英文刊物名称: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
论文全文:
英文论文全文:
全文链接:
其它备注:
英文其它备注:
学科: Materials Science, Biomaterials
英文学科: Materials Science, Biomaterials
影响因子: 4.164
第一作者所在部门:
英文第一作者所在部门:
论文出处:
英文论文出处:
论文类别: Article
英文论文类别: Article
参与作者:
英文参与作者:
 
2014 中国科学院上海生命科学研究院 版权所有